ArticleJournal of visualized experiments : JoVE2015
A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits.
Article in Journal of visualized experiments : JoVE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models.International journal of environmental research and public health · 2021Pooled it
- Review
- Hyperactivity in male and female mice manifests differently following early, acute prenatal alcohol exposure and mild juvenile stress.Frontiers in behavioral neuroscience · 2025Article
- Effects of subchronic and mild social defeat stress on the intestinal microbiota and fecal bile acid composition in mice.Bioscience of microbiota, food and health · 2024Article
- Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.International journal of molecular sciences · 2023Article
- Impacts of Subchronic and Mild Social Defeat Stress on Plasma Putrefactive Metabolites and Cardiovascular Structure in Male Mice.International journal of molecular sciences · 2023Article
- Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach.Brain sciences · 2022Review
- Salivary microRNA and Metabolic Profiles in a Mouse Model of Subchronic and Mild Social Defeat Stress.International journal of molecular sciences · 2022Article
- Home-cage behavior in the Stargazer mutant mouse.Scientific reports · 2022Article
- Effect of ProbioticNutrients · 2022Article
- NFrontiers in cell and developmental biology · 2021Article
- Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice.Physiological reports · 2019Article
- Social defeat models in animal science: What we have learned from rodent models.Animal science journal = Nihon chikusan Gakkaiho · 2017Review
- Murine Depression Model and its Potential Applications for Discovering Foods and Farm Products with Antidepressant-Like Effects.Frontiers in neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stressful life events often increase the incidence of depression in humans. To study the mechanisms of depression, the development of animal models of depression is essential. Because there are several types of depression, various animal models are needed for a deeper understanding of the disorder. Previously, a mouse model of subchronic and mild social defeat stress (sCSDS) using a modified chronic social defeat stress (CSDS) paradigm was established. In the paradigm, to reduce physical injuries from aggressors, the duration of physical contact between the aggressor and a subordinate was reduced compared to in the original CSDS paradigm. sCSDS mice showed increased body weight gain, food intake, and water intake during the stress period, and their social behaviors were suppressed after the stress period. In terms of the face validity of the stress-induced overeating and overdrinking following the increased body weight gain, the sCSDS mice may show some features related to atypical depression in humans. Thus, a mouse model of sCSDS may be useful for studying the pathogenic mechanisms underlying depression. This protocol will help establish the sCSDS mouse model, especially for studying the mechanisms underlying stress-induced weight gain and polydipsia- and hyperphagia-like symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.