ArticlePloS one2015
AtNHX5 and AtNHX6 Control Cellular K+ and pH Homeostasis in Arabidopsis: Three Conserved Acidic Residues Are Essential for K+ Transport.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 53 citations in OpenAlex.
- Impact of alternative splicing on Arabidopsis proteome.Nucleic acids research · 2026Article
- Bioinformatics analysis of the KEA gene family in rice.Open life sciences · 2026Article
- Cloning and Functional Verification of Salt Tolerance GenePlants (Basel, Switzerland) · 2025Article
- Impact of alternative splicing on Arabidopsis proteome.bioRxiv : the preprint server for biology · 2025Article
- A KRice (New York, N.Y.) · 2025Article
- Genome-Wide Identification of the Cation/Proton Antiporter (International journal of molecular sciences · 2025Article
- Diethyl aminoethyl hexanoate ameliorates salt tolerance associated with ion transport, osmotic adjustment, and metabolite reprograming in white clover.BMC plant biology · 2024Article
- Genome-wide identification and drought stress-induced expression analysis of theFrontiers in genetics · 2024Article
- OsCCRL1 is Essential for Phenylpropanoid Metabolism in Rice Anthers.Rice (New York, N.Y.) · 2023Article
- Unfolding molecular switches for salt stress resilience in soybean: recent advances and prospects for salt-tolerant smart plant production.Frontiers in plant science · 2023Review
- The genome of a mangrove plant, Avicennia marina, provides insights into adaptation to coastal intertidal habitats.Planta · 2022Article
- Integrative transcriptome and proteome analyses provide deep insights into the molecular mechanism of salt tolerance in Limonium bicolor.Plant molecular biology · 2022Article
- Metabolites Reprogramming and NaFrontiers in plant science · 2022Article
- A soybean sodium/hydrogen exchanger GmNHX6 confers plant alkaline salt tolerance by regulating NaFrontiers in plant science · 2022Article
- A Golgi-Localized Sodium/Hydrogen Exchanger Positively Regulates Salt Tolerance by Maintaining Higher KFrontiers in plant science · 2021Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2020Article
- A novel tonoplast NaPlant cell reports · 2020Article
- Coordinated Transport of Nitrate, Potassium, and Sodium.Frontiers in plant science · 2020Review
- Could vesicular transport of Na+ and Cl- be a feature of salt tolerance in halophytes?Annals of botany · 2019Article
- KPlant physiology · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
AtNHX5 and AtNHX6, the endosomal Na+,K+/H+ antiporters in Arabidopsis, play an important role in plant growth and development. However, their function in K+ and pH homeostasis remains unclear. In this report, we characterized the function of AtNHX5 and AtNHX6 in K+ and H+ homeostasis in Arabidopsis. Using a yeast expression system, we found that AtNHX5 and AtNHX6 recovered tolerance to high K+ or salt. We further found that AtNHX5 and AtNHX6 functioned at high K+ at acidic pH while AtCHXs at low K+ under alkaline conditions. In addition, we showed that the nhx5 nhx6 double mutant contained less K+ and was sensitive to low K+ treatment. Overexpression of AtNHX5 or AtNHX6 gene in nhx5 nhx6 recovered root growth to the wild-type level. Three conserved acidic residues, D164, E188, and D193 in AtNHX5 and D165, E189, and D194 in AtNHX6, were essential for K+ homeostasis and plant growth. nhx5 nhx6 had a reduced vacuolar and cellular pH as measured with the fluorescent pH indicator BCECF or semimicroelectrode. We further show that AtNHX5 and AtNHX6 are localized to Golgi and TGN. Taken together, AtNHX5 and AtNHX6 play an important role in K+ and pH homeostasis in Arabidopsis. Three conserved acidic residues are essential for K+ transport.
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