ArticlePloS one2015
Whole Transcriptome Analysis Provides Insights into Molecular Mechanisms for Molting in Litopenaeus vannamei.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 136 citations in OpenAlex.
- Molting in Pancrustacea Is Characterized by Both Deeply Conserved and Recently Evolved Gene Modules.Genome biology and evolution · 2026Article
- Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation.Molecular biology and evolution · 2026Article
- Integrating Transcriptomics and Gut Microbiota Analysis Reveals Adaptive Mechanisms of Alkaline Stress on the Molting and Intestinal Immune Responses in Pacific White Shrimp,Life (Basel, Switzerland) · 2026Article
- The epidermal ecotone: a proposed model system for marine viral ecology at the animal-environmental interface.NPJ biofilms and microbiomes · 2026Review
- Sand Substrate Thickness Regulates Growth Performance, Intestinal Antioxidant Defense, and Gut Microbiota in an Experimental Culture ofAnimals : an open access journal from MDPI · 2026Article
- Genome-wide identification and functional characterization of alpha-amylase genes in Litopenaeus vannamei.PloS one · 2026Article
- Seasonality affects key physiological pathways in Pontastacus leptodactylus during an Aphanomyces astaci epidemic outbreak.Scientific reports · 2025Article
- Multi-marker GWAS and variant-specific genomic prediction for growth traits in Pacific white shrimp.Scientific reports · 2025Article
- Ecytonucleospora hepatopenaei causes lipid droplet depletion and imbalanced lipid metabolism in Penaeus vannamei.Scientific reports · 2025Article
- TDO-mediated tissue-specific regulation of kynurenine pathway in the brain and gill of Litopenaeus vannamei.BMC genomics · 2025Article
- Key Neuropeptides Regulating Molting in Pacific White Shrimp (Animals : an open access journal from MDPI · 2025Article
- Transcriptome Analysis Reveals the Key Genes and Pathways for Growth, Ion Transport, and Oxidative Stress in Post-Larval Black Tiger Shrimp (Penaeus monodon) Under Acute Low Salt Stress.Marine biotechnology (New York, N.Y.) · 2025Article
- Identification of Key Genes Correlated with Economic Trait Superiorities and Their SNP Screening Through Transcriptome Comparisons, WGCNA and Pearson Correlation Coefficient in the Sea Cucumber Apostichopus Japonicus.Marine biotechnology (New York, N.Y.) · 2024Article
- Identification and Characterization of a Novel Insulin-like Receptor (Biomolecules · 2024Article
- A Comparative Analysis of the Anti-Tumor Activity of Sixteen Polysaccharide Fractions from Three Large Brown Seaweed,Marine drugs · 2024Article
- Review
- Deciphering Molecular Mechanisms Governing the Reproductive Molt ofInternational journal of molecular sciences · 2023Article
- Gene Structure, Expression and Function Analysis ofInternational journal of molecular sciences · 2023Article
- Combined analysis of mRNA and miRNA reveals the mechanism of pacific white shrimp (Litopenaeus vannamei) under acute alkalinity stress.PloS one · 2023Article
- Structure and function analyses of the Mmd2 gene in pacific white shrimpFrontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molting is one of the most important biological processes in shrimp growth and development. All shrimp undergo cyclic molting periodically to shed and replace their exoskeletons. This process is essential for growth, metamorphosis, and reproduction in shrimp. However, the molecular mechanisms underlying shrimp molting remain poorly understood. In this study, we investigated global expression changes in the transcriptomes of the Pacific white shrimp, Litopenaeus vannamei, the most commonly cultured shrimp species worldwide. The transcriptome of whole L. vannamei was investigated by RNA-sequencing (RNA-seq) throughout the molting cycle, including the inter-molt (C), pre-molt (D0, D1, D2, D3, D4), and post-molt (P1 and P2) stages, and 93,756 unigenes were identified. Among these genes, we identified 5,117 genes differentially expressed (log2ratio ≥1 and FDR ≤0.001) in adjacent molt stages. The results were compared against the National Center for Biotechnology Information (NCBI) non-redundant protein/nucleotide sequence database, Swiss-Prot, PFAM database, the Gene Ontology database, and the Kyoto Encyclopedia of Genes and Genomes database in order to annotate gene descriptions, associate them with gene ontology terms, and assign them to pathways. The expression patterns for genes involved in several molecular events critical for molting, such as hormone regulation, triggering events, implementation phases, skelemin, immune responses were characterized and considered as mechanisms underlying molting in L. vannamei. Comparisons with transcriptomic analyses in other arthropods were also performed. The characterization of major transcriptional changes in genes involved in the molting cycle provides candidates for future investigation of the molecular mechanisms. The data generated in this study will serve as an important transcriptomic resource for the shrimp research community to facilitate gene and genome annotation and to characterize key molecular processes underlying shrimp development.
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