ArticleAnnals of the American Thoracic Society2016
Validation of a Method to Identify Immunocompromised Patients with Severe Sepsis in Administrative Databases.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Disparities in COVID-19 mortality amongst the immunosuppressed: A systematic review and meta-analysis for enhanced disease surveillance.The Journal of infection · 2024Pooled it
- Acute abdomen in the immunocompromised patient: WSES, SIS-E, WSIS, AAST, and GAIS guidelines.World journal of emergency surgery : WJES · 2021Guideline
- Surgical site infection prevention and management in immunocompromised patients: a systematic review of the literature.World journal of emergency surgery : WJES · 2021Pooled it
- Clinical characteristics and prognostic analysis of sepsis in immunocompromised and non-immunocompromised patients: a prospective cohort study in the emergency department.BMC infectious diseases · 2026Article
- Large language models accurately identify immunosuppression in intensive care unit patients.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- A New Emerging Threat in Critical Care:Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Large language models outperform traditional structured data-based approaches in identifying immunosuppressed patients.medRxiv : the preprint server for health sciences · 2025Article
- Effectiveness of the influenza vaccine for preventing laboratory-confirmed influenza infections in outpatient immunocompromised adults, 2017-2018.Human vaccines & immunotherapeutics · 2024Article
- Long-term treatment outcomes of complicated acute diverticulitis in immunocompromised patients.International journal of colorectal disease · 2024Article
- A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants.Frontiers in public health · 2024Review
- Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network.Frontiers in immunology · 2024Article
- Detection of SARS-CoV-2 Δ426 ORF8 Deletion Mutant Cluster in NGS Screening.Microorganisms · 2023Article
- Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T).Techniques in coloproctology · 2023Article
- Vaccine Effectiveness of JYNNEOS against Mpox Disease in the United States.The New England journal of medicine · 2023Article
- Analysis of mRNA COVID-19 Vaccine Uptake Among Immunocompromised Individuals in a Large US Health System.JAMA network open · 2023Article
- Epidemiology of ICU-Onset Bloodstream Infection: Prevalence, Pathogens, and Risk Factors Among 150,948 ICU Patients at 85 U.S. Hospitals.Critical care medicine · 2022Article
- Immunostimulatory Activity ofMicroorganisms · 2022Article
- A Proposal for a Classification Guiding the Selection of Appropriate Antibiotic Therapy for Intra-Abdominal Infections.Antibiotics (Basel, Switzerland) · 2022Review
- Validity of operative information in Japanese administrative data: a chart review-based analysis of 1221 cases at a single institution.Surgery today · 2022Review
- mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients.The Journal of infectious diseases · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
rationaleImmunocompromised patients are at high risk for developing severe sepsis. Currently, there are no validated strategies for identifying this group of patients in large administrative databases.
objectivesWe set out to define and validate a method that could be used to identify immunocompromised patients with severe sepsis in administrative databases.
methodsPatients were categorized as immunocompromised based on the presence of International Classification of Diseases, 9th revision discharge diagnosis codes and medication data. We validated this strategy by comparing the discriminatory ability of the search algorithm to that of manual chart review. MEASUREMENTS AND MAIN
resultsWe identified 4,438 patients at a single academic center with severe sepsis using a definition applied to administrative data described by Angus and colleagues. There were 1,185 (26.7%) who were categorized as immunocompromised based on our novel administrative data search strategy. Compared with identification by medical record review, the new administrative data search strategy had positive and negative predictive values of 94.4% (95% confidence interval [CI], 88.8-97.7%) and 94.3% (95% CI, 91.0-96.6%). The sensitivity and specificity were 87.4% (95% CI, 80.6-92.5%) and 97.6% (95% CI, 95.0-99.9%).
conclusionsPatients who are immunosuppressed are a large subgroup of those with severe sepsis. Following its validation as a search strategy using other large databases, and its adaptation for International Classification of Diseases, 10th revision, this novel method may allow researchers to account for a patient's immune state when examining outcomes.
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