ArticleMolecular imaging2015
Digital Microfluidics: A New Paradigm for Radiochemistry.
Article in Molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Orbital Electrowetting: From Continuous Droplet Transport to Programmable Microfluidics.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Proof-of-concept optimization of a copper-mediatedLab on a chip · 2023Article
- Graphene Oxide Paper Manipulation of Micro-Reactor Drops.Micromachines · 2023Article
- Economical droplet-based microfluidic production of [Scientific reports · 2021Article
- Optimization of Radiochemical Reactions using Droplet Arrays.Journal of visualized experiments : JoVE · 2021Article
- Cerenkov Luminescence Imaging in the Development and Production of Radiopharmaceuticals.Frontiers in physics · 2021Article
- High-Yielding Radiosynthesis of [Molecular imaging and biology · 2020Article
- The Current Role of Microfluidics in Radiofluorination Chemistry.Molecular imaging and biology · 2020Review
- Multi-GBq production of the radiotracer [RSC advances · 2020Article
- Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[EJNMMI radiopharmacy and chemistry · 2019Article
- Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production.EJNMMI radiopharmacy and chemistry · 2019Article
- Ultra-compact, automated microdroplet radiosynthesizer.Lab on a chip · 2019Article
- A novel multi-reaction microdroplet platform for rapid radiochemistry optimization.RSC advances · 2019Article
- Automated concentration of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2018Article
- Microscale radiosynthesis, preclinical imaging and dosimetry study of [Nuclear medicine and biology · 2018Article
- The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: Application toEuropean journal of medicinal chemistry · 2018Article
- Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography.Communications chemistry · 2018Article
- Performing multi-step chemical reactions in microliter-sized droplets by leveraging a simple passive transport mechanism.Lab on a chip · 2017Article
- Recent Progress toward Microfluidic Quality Control Testing of Radiopharmaceuticals.Micromachines · 2017Review
- Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation.Lab on a chip · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The emerging technology of digital microfluidics is opening up the possibility of performing radiochemistry at the microliter scale to produce tracers for positron emission tomography (PET) labeled with fluorine-18 or other isotopes. Working at this volume scale not only reduces reagent costs but also improves specific activity (SA) by reducing contamination by the stable isotope. This technology could provide a practical means to routinely prepare high-SA tracers for applications such as neuroimaging and could make it possible to routinely achieve high SA using synthesis strategies such as isotopic exchange. Reagent droplets are controlled electronically, providing high reliability, a compact control system, and flexibility for diverse syntheses with a single-chip design. The compact size may enable the development of a self-shielded synthesizer that does not require a hot cell. This article reviews the progress of this technology and its application to the synthesis of PET tracers.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.