SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2016
Does dienogest influence the inflammatory response of endometriotic cells? A systematic review.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05937490 (Assisted Reproductive Technology), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assisted Reproductive Technology (ART) and Pregnancy Outcomes in Women With Adenomyosis (Internal Endometriosis) According to Stimulation Protocol in Relation to Immunological and Endometrial Features: a Prospective, Randomized Study
Who cites it
21 citing papers in PubMed, 75 citations in OpenAlex.
- Impact of perioperative use of GnRH agonist or dienogest on ovarian reserve after cystectomy for endometriomas: a randomized controlled trial.Reproductive biology and endocrinology : RB&E · 2021Trial
- A novel approach to treating Endometriosis-Related Repeated IVF failures- insights from single case report.Reproductive biology and endocrinology : RB&E · 2026Article
- Terazosin as a Non-Hormonal Treatment for Endometriosis.International journal of molecular sciences · 2026Article
- Clinical Efficacy of Dienogest for Symptomatic Adenomyosis.Journal of clinical medicine · 2026Article
- An Overview of Endometriosis and Potential Pharmacogenetic Targets.Pharmaceutical research · 2026Review
- Endometriosis-associated bone loss: re-evaluating the potential role of systemic inflammation and hypoestrogenic therapies.Frontiers in global women's health · 2026Review
- Do NGF and LPS Interact Synergistically to Modulate Inflammation in Sheep Endometrial Epithelial Cells?International journal of molecular sciences · 2025Article
- Long-term follow-up of the effect of oral dienogest and dienogest/ethinylestradiol treatment on cell-free DNA levels in patients with deep endometriosis.European journal of medical research · 2025Observational
- Azurocidin is Associated with Dienogest-resistance in Ovarian Endometriotic Cysts.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Effects of dienogest treatment on endometrioma-related clinical symptoms and endometrioma size: retrospective cohort study.Frontiers in medicine · 2025Article
- Characterization of the vaginal microbiota in Italian women with endometriosis: preliminary study.Archives of gynecology and obstetrics · 2024Article
- Evaluation of long-term efficacy and safety of dienogest in patients with chronic cyclic pelvic pain associated with endometriosis.Archives of gynecology and obstetrics · 2024Observational
- Dienogest in endometriosis treatment: A narrative literature review.Clinical and experimental reproductive medicine · 2023Article
- Sulawesi propolis induces higher apoptotic activity and lower inflammatory activity in a rat endometriosis model.European journal of obstetrics & gynecology and reproductive biology: X · 2023Article
- Clinical Diagnosis and Early Medical Management for Endometriosis: Consensus from Asian Expert Group.Healthcare (Basel, Switzerland) · 2022Review
- Computer-Aided Histopathological Characterisation of Endometriosis Lesions.Journal of personalized medicine · 2022Article
- Progesterone as an Anti-Inflammatory Drug and Immunomodulator: New Aspects in Hormonal Regulation of the Inflammation.Biomolecules · 2022Review
- Expression of Matrix Metalloproteinases and Their Inhibitors in Endometrium: High Levels in Endometriotic Lesions.International journal of molecular sciences · 2020Article
- Long-Term Administration of Dienogest for the Treatment of Pain and Intestinal Symptoms in Patients with Rectosigmoid Endometriosis.Journal of clinical medicine · 2020Article
- Cyclooxygenase-2 in Endometriosis.International journal of biological sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designA systematic review of all literature was done to assess the ability of the progestin dienogest (DNG) to influence the inflammatory response of endometriotic cells.
main outcome measuresIn vitro and in vivo studies report an influence of DNG on the inflammatory response in eutopic or ectopic endometrial tissue (animal or human).
resultsAfter strict inclusion criteria were satisfied, 15 studies were identified that reported a DNG influence on the inflammatory response in endometrial tissue. These studies identified a modulation of prostaglandin (PG) production and metabolism (PGE2, PGE2 synthase, cyclo-oxygenase-2 and microsomal PGE synthase-1), pro-inflammatory cytokine and chemokine production [interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α, monocyte chemoattractant protein-1 and stromal cell-derived factor-1], growth factor biosynthesis (vascular endothelial growth factor and nerve growth factor) and signaling kinases, responsible for the control of inflammation. Evidence supports a progesterone receptor-mediated inhibition of the inflammatory response in PR-expressing epithelial cells. It also indicated that DNG inhibited the inflammatory response in stromal cells, however, whether this was via a PR-mediated mechanism is not clear.
conclusionsDNG has a significant effect on the inflammatory microenvironment of endometriotic lesions that may contribute to its clinical efficacy. A better understanding of the specific anti-inflammatory activity of DNG and whether this contributes to its clinical efficacy can help develop treatments that focus on the inhibition of inflammation while minimizing hormonal modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.