ArticleNature2015
Acute off-target effects of neural circuit manipulations.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
212 citing papers in PubMed, 1 synthesis or guideline pooled it, 375 citations in OpenAlex.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Sensory-to-motor transformations: From serial pipelines to dynamic, distributed processes.Neuroscience and biobehavioral reviews · 2026Review
- A conserved pulvinar projection to the amygdala revealed in macaque monkeys (Macaca mulatta).Brain structure & function · 2026Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Spectral dependence as a framework for neural coordination.Current research in neurobiology · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Addressing degeneracy in rodent studies of cognition.Current opinion in neurobiology · 2026Review
- The anterior cingulate cortex modulates pupil-linked arousal.Science advances · 2026Article
- Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.Current biology : CB · 2026Article
- Probabilistic Perceptual Decisions during Navigation Are Driven by a Small Subpopulation of Neurons in a Single Cortical Column of the Primary Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- High-throughput assessment of vocal modulation following chemogenetic inhibition in songbirds.iScience · 2026Article
- Temperature robustness of the timing network within songbird premotor nucleus HVC.Journal of computational neuroscience · 2026Article
- Bridging the translational gap in systems neuroscience: from circuit mechanisms to clinical therapeutics.Frontiers in pharmacology · 2026Review
- Structural covariance network in the striatum is modulated by non-suicidal self-injury in adolescents with major depressive disorder.BMC psychiatry · 2025Article
- A neural circuit for context-dependent multimodal signaling in Drosophila.Nature communications · 2025Article
- Sparse memory ensembles set brain-wide network states to sustain learned associations.iScience · 2025Article
- Dissociating instructive from permissive roles of brain circuits with reversible neural activity manipulations.bioRxiv : the preprint server for biology · 2025Article
152 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid and reversible manipulations of neural activity in behaving animals are transforming our understanding of brain function. An important assumption underlying much of this work is that evoked behavioural changes reflect the function of the manipulated circuits. We show that this assumption is problematic because it disregards indirect effects on the independent functions of downstream circuits. Transient inactivations of motor cortex in rats and nucleus interface (Nif) in songbirds severely degraded task-specific movement patterns and courtship songs, respectively, which are learned skills that recover spontaneously after permanent lesions of the same areas. We resolve this discrepancy in songbirds, showing that Nif silencing acutely affects the function of HVC, a downstream song control nucleus. Paralleling song recovery, the off-target effects resolved within days of Nif lesions, a recovery consistent with homeostatic regulation of neural activity in HVC. These results have implications for interpreting transient circuit manipulations and for understanding recovery after brain lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.