ReviewBioMed research international2015
Ordinary and Activated Bone Grafts: Applied Classification and the Main Features.
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03076138 (The Clinical Trial of the Safety and Efficacy of the Medical Device "Bone Substitute Based on Octacalcium Phosphate and Biologically Active Nucleic Acids for Bone Tissue Regeneration"), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical Trial of the Safety and Efficacy of the Medical Device "Bone Substitute Based on Octacalcium Phosphate and Biologically Active Nucleic Acids for Bone Tissue Regeneration" (Nucleostim-VEGF)
Who cites it
14 citing papers in PubMed.
- Research Progress of Bone Grafting: A Comprehensive Review.International journal of nanomedicine · 2025Review
- Endogenous Regeneration of Alveolar Bone by Decellularized Tooth Matrix.Bulletin of experimental biology and medicine · 2023Article
- Comparative Efficiency of Gene-Activated Matrices Based on Chitosan Hydrogel and PRP Impregnated withInternational journal of molecular sciences · 2022Article
- Bone Augmentation for Implant Placement: Recent Advances.International journal of dentistry · 2022Review
- Nanocomposites of Chitosan/Graphene Oxide/Titanium Dioxide Nanoparticles/Blackberry Waste Extract as Potential Bone Substitutes.Polymers · 2021Article
- Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments.Molecules (Basel, Switzerland) · 2021Review
- Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside.Frontiers in bioengineering and biotechnology · 2021Article
- Physical/Chemical Properties and Resorption Behavior of a Newly Developed Ca/P/S-Based Bone Substitute Material.Materials (Basel, Switzerland) · 2020Article
- Development prospects of curable osteoplastic materials in dentistry and maxillofacial surgery.Heliyon · 2020Review
- Injectable porcine bone demineralized and digested extracellular matrix-PEGDA hydrogel blend for bone regeneration.Journal of materials science. Materials in medicine · 2020Article
- 3D Printed Gene-activated Octacalcium Phosphate Implants for Large Bone Defects Engineering.International journal of bioprinting · 2020Article
- Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies.Frontiers in cell and developmental biology · 2020Review
- Comment on "World's First Clinical Case of Gene-Activated Bone Substitute Application".Case reports in dentistry · 2017Article
- World's First Clinical Case of Gene-Activated Bone Substitute Application.Case reports in dentistry · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone grafts are medical devices that are in high demand in clinical practice for substitution of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern groups of bone grafts, the particularities of their composition, the mechanisms of their biological effects, and their therapeutic indications, applicable classification was proposed that separates the bone substitutes into "ordinary" and "activated." The main differential criterion is the presence of biologically active components in the material that are standardized by qualitative and quantitative parameters: growth factors, cells, or gene constructions encoding growth factors. The pronounced osteoinductive and (or) osteogenic properties of activated osteoplastic materials allow drawing upon their efficacy in the substitution of large bone defects.
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Registered trials
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