Evidence map›Paper›PMID 26649106›Full record

SynthesisOntario health technology assessment series2015

Patient Perspectives on Quality of Life With Uncontrolled Type 1 Diabetes Mellitus: A Systematic Review and Qualitative Meta-synthesis.

Meredith Vanstone, Alex Rewegan, Francesca Brundisini, Deirdre Dejean, Mita Giacomini

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC
In one paragraph

Synthesis in Ontario health technology assessment series, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  5. Family member involvement when multiple family members have type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2025
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  17. Time for changes in type 1 diabetes intervention trial designs.The lancet. Diabetes & endocrinology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Meredith VanstoneDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario ; Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario.
Alex ReweganDepartment of Family Medicine, McMaster University, Hamilton, Ontario.
Francesca BrundisiniCentre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario ; Health Policy PhD Program, McMaster University, Hamilton, Ontario.
Deirdre DejeanDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario ; Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario.
Mita GiacominiDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario ; Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario.
McMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with uncontrolled type 1 diabetes mellitus may be candidates for pancreatic islet cell transplantation. This report synthesizes qualitative research on how patients with uncontrolled type 1 diabetes perceive their quality of life.

objectiveThe objective of this analysis was to examine the perceptions of patients with uncontrolled type 1 diabetes on how it affects their lived experience and quality of life. DATA SOURCES: This report synthesizes 31 primary qualitative studies to examine quality of life from the perspectives of adult patients with type 1 diabetes mellitus and their families or partners. REVIEW

methodsWe performed a qualitative meta-synthesis to integrate findings across primary research studies.

resultsLong- and short-term negative consequences of uncontrolled type 1 diabetes affect all aspects of patients' lives: physical, emotional, practical, and social. The effect on each domain is far-reaching, and effects interact across domains. Uncontrolled blood sugar levels lead to substantial psychological distress, negative moods, cognitive difficulties, irritable or aggressive behaviour, and closely associated problems with relationships, self-image, and confidence. Emotional distress is pervasive and under-addressed by health care providers. Patients live in fear of complications from diabetes over the long term. In the shorter term, they are anxious about the personal, social, and professional consequences of hypoglycemic episodes (e.g., injury, humiliation), and may curtail normal activities such as driving or socializing because they are worried about having an episode. The quality of life for patients' family members is also negatively impacted by uncontrolled type 1 diabetes.

conclusionsUncontrolled type 1 diabetes has significant negative impacts on the quality of life of both people with the disease and their families.

Indexed as

Quality of LifeDiabetes Mellitus, Type 1HumansMental DisordersQualitative ResearchSelf CareStress, Psychological

Identifiers

PMID26649106
PMCPMC4664939
OpenAlexW2419294194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.