Evidence map›Paper›PMID 26649038›Full record

ArticleInternational journal of endocrinology2015

Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population.

Lifeng Ning, Yaqin Yu, Xiaoli Liu, Lizhe Ai, Xin Zhang, Wenwang Rao, Jieping Shi, Hui Sun, Qiong Yu

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Article in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lifeng NingDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; National Research Institute for Family Planning, Beijing 100081, China.
Yaqin YuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Xiaoli LiuJilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Lizhe AiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Xin ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Wenwang RaoDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Jieping ShiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Hui SunJilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Qiong YuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the association of MET SNPs with gender disparity in thyroid tumors, as well as the metastasis and prognosis of patients, 858 patients with papillary thyroid carcinoma (PTC), 556 patients with nodular goiter, and 896 population-based normal controls were recruited. The genotyping of MET SNPs was carried out using the Sequenom MassARRAY system. The distribution of MET SNPs (rs1621 and rs6566) was different among groups. Gender stratification analysis revealed a significant association between the rs1621 genotype and PTC in female patients (P = 0.037), but not in male patients (P > 0.05). For female patients, the rs1621 AG genotype was significantly higher in patients with PTC than in normal controls (P = 0.01) and revealed an increasing risk of PTC (OR: 1.465, 95% CI: 1.118-1.92). However, association analysis of the rs1621 genotype with metastasis and prognosis revealed no significant correlation in both male and female patients. The findings of our study showed that polymorphism of SNP locus rs1621 in MET gene may be associated with gender disparity in PTC. Higher AG genotypes in rs1621 were correlated with PTC in female patients, but not in male patients.

Identifiers

PMID26649038
PMCPMC4662967

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