Evidence map›Paper›PMID 26649006›Full record

ArticlePakistan journal of medical sciences

Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population.

Matin Kayyal, Abolfazl Movafagh, Mehrdad Hashemi, Arezou Sayad, Babak Emamalizadeh, Khashayar PourIran, Mohammadmoien Kayyal, Mohammad Reza Eslami Amirabadi, Mahdi Zamani, Hossein Darvish

Open access · goldAbstract read
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In one paragraph

Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Matin KayyalMatin Kayyal, Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
Abolfazl MovafaghAbolfazl Movafagh, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehrdad HashemiMehrdad Hashemi, Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
Arezou SayadArezou Sayad, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Babak EmamalizadehBabak Emamalizadeh, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Khashayar PourIranKhashayar pourIran, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammadmoien KayyalMohammadmoien Kayyal, Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
Mohammad Reza Eslami AmirabadiMohammad Reza Eslami Amirabadi, Department of Psychiatry, Imam Hossein Medical Hospital, Shahid Behashti University of Medical Sciences, Tehran, Iran.
Mahdi ZamaniMahdi Zamani Department of Medical Genetics, School of Medicine, Department of Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Hossein DarvishHossein Darvish, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Medical Genetics Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesAttention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs rs11122319, rs11122330 and rs6675281 in the etiology of ADHD in an Iranian children.

methodsIn this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISC1 gene with ADHD in Iranian population. Two hundred fourthy subjects composed of 120 patients and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs.

resultsWe found differences in genotype and allele distributions of rs 6675281 polymorphism between our patients and controls. The A, T and A alleles were the more frequent alleles in rs11122319, rs6675281 and rs11122330 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to patients. (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776).

conclusionOur findings strengthens the role of DISC1 gene as a susceptibility locus for ADHD and indicate that rs6675281 polymorphism is a susceptibility factor for ADHD for the first time in children reported in an Iranian population in this part of the world.

Indexed as

ADHDAssociationDISC1 geneHyperactivityIranpolymorphisms

Identifiers

PMID26649006
PMCPMC4641275
OpenAlexW2432225226

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.