ArticleEXCLI journal2015
Sleep deprivation-induced multi-organ injury: role of oxidative stress and inflammation.
Article in EXCLI journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models.BMC medicine · 2026Pooled it
- A Novel Systematic Oxidative Stress Score Predicts the Prognosis of Patients with Operable Breast Cancer.Oxidative medicine and cellular longevity · 2021Trial
- Effects of Statin on Arrhythmia and Heart Rate Variability in Healthy Persons With 48-Hour Sleep Deprivation.Journal of the American Heart Association · 2016Trial
- Sleep restriction induces histoarchitectural and cellular remodeling in the rat distal colon: a peripheral consequence of circadian disruption.Biochemistry and biophysics reports · 2026Article
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
- Chronic Sleep Disturbance Enhances Inflammation and Collagen Production in Neural- and Myofascial Tissues in Uninjured Rats.International journal of molecular sciences · 2026Article
- Gestational sleep deprivation-induced changes in serum hormone concentrations and testicular oxidative stress affect spermatogenesis in postpubertal male offspring of mice.Asian journal of andrology · 2026Article
- Maternal sleep deprivation and developmental programming of brain aging trajectories in offspring.Biogerontology · 2026Review
- Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation.Sleep science (Sao Paulo, Brazil) · 2026Article
- Sleep regulates hepatic neutrophil trafficking by modulating uric acid metabolism via sympathetic nervous system activity.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial dysfunction in sleep deprivation.Metabolic brain disease · 2026Review
- Dietary astragalus stems polysaccharides improve antioxidant capacity and lactation performance in dairy goats through integrated metabolomic and mechanistic analyses.Scientific reports · 2026Article
- Characterizing insomnia and sleep quality in a cohort with tension type headache.Open medicine (Warsaw, Poland) · 2026Article
- Oxidative Stress Inflammation Score is the Optimal Inflammatory Prognostic Indicator for Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Immunochemotherapy: A Multicenter Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- Inflammation in Neuronal Intranuclear Inclusion Disease (NIID): mechanisms, biomarkers, and therapeutic implications.Journal of neuroinflammation · 2025Review
- Exogenous Melatonin Attenuates Sleep Restriction-Induced Kidney Injury via Gut Microbiota-Derived Propionate in Mice.Antioxidants (Basel, Switzerland) · 2025Article
- Cornelian Cherry (Biology · 2025Article
- Oxidative Stress Score as a Simplified Surrogate for Prognostic Stratification and Therapeutic Decision-Making in Multiple Myeloma.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The Effects and Mechanisms of Continuous 7-Day Hypobaric Hypoxia Exposure on Sleep Architecture in Rats.International journal of molecular sciences · 2025Article
- Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions.Neurobiology of sleep and circadian rhythms · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep deprivation affects all aspects of health. Adverse health effects by sleep deviation are still underestimated and undervalued in clinical practice and, to a much greater extent in monitoring human health. We hypothesized that sleep deprivation-induced mild organ injuries; oxidative stress and inflammation might play a crucial role in inducing multi-organ injury. Male C57BL/6J mice (n = 6-7) were sleep-deprived for 0-72 h using a modified multiple platform boxes method. Blood and tissue were collected. Liver, heart, kidney, lung, and pancreatic injuries were evaluated using biochemical and histological analyses. Glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), total billirubin (TBIL), creatine phosphokinase (CPK), creatine phosphokinase-myocardial band (CKMB), lactic dehydrogenase (LDH), creatinine (CRE), and blood urea nitrogen (BUN) were assayed in blood. Malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 levels were measured. Histology revealed mild-to-moderate liver and lung injury in sleep-deprived mice. Sleep-deprived mice had significantly higher GOT, GPT, TBIL, CPK, CKMB, LDH, BUN, and α-amylase (AMYL) levels, which indicated liver, heart, kidney, and pancreatic injuries. Serum IL-1β at 24 h and IL-6 at 72 h were significantly higher in sleep-deprived than in control mice. Hepatic TNF-α and IL-1β were significantly higher, but IL-6 significantly lower in mice that had been sleep-deprived for 72 h. Sleep deprivation-mediated inflammation may be associated with mild to moderate multi-organ damage in mice. The implication of this study indicates sleep deprivation in humans may induce multi-organ injury that negatively affects cardiovascular and gastrointestinal health.
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Registered trials
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