ArticleCentral-European journal of immunology2015
Elevated expression of interleukin-21 and its correlation to T-cell subpopulation in patients with ulcerative colitis.
Article in Central-European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Colorectal Cancer in Ulcerative Colitis: Mechanisms, Surveillance and Chemoprevention.Current oncology (Toronto, Ont.) · 2022Review
- The Role of T Follicular Helper Cells and Interleukin-21 in the Pathogenesis of Inflammatory Bowel Disease.Gastroenterology research and practice · 2021Review
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the expression of interleukin-21 (IL-21) and its correlation to T-cell subpopulation including Th1, Tc1 and Th17 cells in Ulcerative colitis (UC). MATERIAL AND
methodsWe examined the expression of IL-21, IL-17 and IFN-γ in UC patients and controls by enzyme-linked immunosorbent assay (ELISA) and flow cytometry.
resultsWe found that IL-21 was expressed on CD3(+)CD8(-)T cells by flow cytometry. Plasma IL-21 level and the percentage of CD3(+)CD8(-)IL-21(+) T cells were significantly elevated in UC patients compared to controls. The percentage of CD3(+)CD8(-)IL-17(+) T (Th17), CD3(+)CD8(-)IFN-γ(+) T (Th1) and CD3(+)CD8(+) IFN-γ(+) T (Tc1) cells was also significantly increased in UC patients. Moreover, we found a significant positive correlation between CD3(+)CD8(-)IL-21(+)T cells and Th17 cells.
conclusionsElevated IL-21 and its positive correlation to Th17 cells may play a role in the pathogenesis of UC.
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