ArticleInternational journal of nanomedicine2015
The diameter of nanotubes formed on Ti-6Al-4V alloy controls the adhesion and differentiation of Saos-2 cells.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Design strategies for chemical-stimuli-responsive programmable nanotherapeutics.Drug discovery today · 2019Pooled it
- Nanotube Size Alters Corrosion Behavior, Mechanical Properties, and Biological Interactions of Anodized Ti6Al7Nb.ACS omega · 2026Article
- Preparation of hydrogel microsphere and its application in articular cartilage injury.Materials today. Bio · 2025Review
- Differential expression of osteoblast-like cells on self-organized titanium dioxide nanotubes.Journal of dental sciences · 2024Article
- Histochemistry for Molecular Imaging in Nanomedicine.International journal of molecular sciences · 2024Review
- Enhancement of biocompatibility of anodic nanotube structures on biomedical Ti-6Al-4V alloy via ultrathin TiOFrontiers in bioengineering and biotechnology · 2024Article
- Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation.Bioactive materials · 2023Review
- Study on the influence of scaffold morphology and structure on osteogenic performance.Frontiers in bioengineering and biotechnology · 2023Review
- A Ru/RuOMaterials (Basel, Switzerland) · 2021Article
- On Growth and Morphology of TiOMaterials (Basel, Switzerland) · 2021Article
- Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?Ceramics international · 2021Review
- Effect of TiONanomaterials (Basel, Switzerland) · 2020Article
- Mesenchymal stem cell interaction with TiRSC advances · 2020Article
- Surface-Dependent Osteoblasts Response to TiONanomaterials (Basel, Switzerland) · 2020Article
- Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation.Materials (Basel, Switzerland) · 2020Article
- Article
- Adhesion and differentiation of Saos-2 osteoblast-like cells on chromium-doped diamond-like carbon coatings.Journal of materials science. Materials in medicine · 2017Article
- Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection.Materials (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ti-6Al-4V-based nanotubes were prepared on a Ti-6Al-4V surface by anodic oxidation on 10 V, 20 V, and 30 V samples. The 10 V, 20 V, and 30 V samples and a control smooth Ti-6Al-4V sample were evaluated in terms of their chemical composition, diameter distribution, and cellular response. The surfaces of the 10 V, 20 V, and 30 V samples consisted of nanotubes of a relatively wide range of diameters that increased with the voltage. Saos-2 cells had a similar initial adhesion on all nanotube samples to the control Ti-6Al-4V sample, but it was lower than on glass. On day 3, the highest concentrations of both vinculin and talin measured by enzyme-linked immunosorbent assay and intensity of immunofluorescence staining were on 30 V nanotubes. On the other hand, the highest concentrations of ALP, type I collagen, and osteopontin were found on 10 V and 20 V samples. The final cellular densities on 10 V, 20 V, and 30 V samples were higher than on glass. Therefore, the controlled anodization of Ti-6Al-4V seems to be a useful tool for preparing nanostructured materials with desirable biological properties.
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