ArticleInternational journal of chronic obstructive pulmonary disease2015
Hyperuricemia is a biomarker of early mortality in patients with chronic obstructive pulmonary disease.
Article in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The importance of uric acid levels in geriatric patients with respiratory failure under noninvasive mechanical ventilation in the respiratory intensive care unit.BMC pulmonary medicine · 2025Article
- Robust positive association between serum urate and the risk of chronic obstructive pulmonary disease: hospital-based cohort and Mendelian randomisation study.BMJ open respiratory research · 2024Article
- Knowledge, attitude, and practice toward hyperuricemia among healthcare workers in Shandong, China.PeerJ · 2024Article
- Sex differences in comorbidities and mortality risk among patients with chronic obstructive pulmonary disease: a study based on NHANES data.BMC pulmonary medicine · 2023Article
- The Diagnosis and Treatment of COPD and Its Comorbidities.Deutsches Arzteblatt international · 2023Review
- Association between right ventricular dysfunction and adverse cardiac events in mild COPD patients.European journal of clinical investigation · 2023Observational
- Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET.Scientific reports · 2022Observational
- U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia.Redox biology · 2022Review
- Association Between Serum Uric Acid and Lung Function in People with and without Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022Article
- Predictors of Renal Function Worsening in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Multicenter Observational Study.Nutrients · 2021Observational
- Effect of Urate-Lowering Therapy on the Progression of Kidney Function in Patients With Asymptomatic Hyperuricemia: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2021Review
- Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk: 2021 update.Cardiology journal · 2021Article
- The Effect of Serum Electrolyte Disturbances and Uric Acid Level on the Mortality of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.Turkish thoracic journal · 2020Article
- Hyperuricemia Is Not Predictive of Long-Term Outcome in Patients with Stable Chronic Obstructive Pulmonary Disease.Journal of Korean medical science · 2020Article
- Pathophysiology of hyperuricemia and its clinical significance - a narrative review.Reumatologia · 2020Review
- Article
- Decreased Serum Bilirubin Levels and Increased Uric Acid Levels are Associated with Ulcerative Colitis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach.Respiratory research · 2018Article
- Serum Uric Acid in Chronic Obstructive Pulmonary Disease: A Hospital Based Case Control Study.Journal of clinical and diagnostic research : JCDR · 2017Article
- The Relation of Moderate Alcohol Consumption to Hyperuricemia in a Rural General Population.International journal of environmental research and public health · 2016Article
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4 authors.
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Abstract
Patients with chronic obstructive pulmonary disease (COPD) are often at high risk of early death. Identification of prognostic biomarkers for COPD may aid in improving their survival by providing early strengthened therapy for high-risk patients. In the present study, we investigated the prognostic role of hyperuricemia at baseline on the prognosis of patients with COPD. Thirty-four patients with COPD with hyperuricemia were matched (1:2) to 68 patients with COPD without hyperuricemia and of similar age and sex. Data from those patients with COPD were evaluated retrospectively. The role of hyperuricemia on mortality was first analyzed using the Kaplan-Meier method, and multivariate Cox regression model was then used to evaluate the prognostic significance of hyperuricemia in patients with COPD. Hyperuricemia was not associated with other baseline characteristics in patients with COPD. Kaplan-Meier survival curve showed that patients with COPD with hyperuricemia had higher risk of mortality compared with patients with normouricemia, and the P-value for log-rank test was 0.005. In univariate analysis, hyperuricemia was associated with higher risk of mortality in patients with COPD (hazard ratio =2.29, 95% CI =1.07-4.88, P=0.032). In the multivariate analysis, hyperuricemia was independently associated with higher risk of mortality in patients with COPD (hazard ratio =2.68, 95% CI =1.18-6.09, P=0.019). In conclusion, hyperuricemia is a promising biomarker of early mortality in patients with COPD.
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