ReviewAustralian prescriber2015
Management of benzodiazepine misuse and dependence.
Review in Australian prescriber, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05568381 (Sleep Disturbance in MCI), which is not on this map. Cited by 103 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep Disturbance in MCI: A Pilot Study of a Cognitive Behavioural Therapy Digital Intervention (SUCCEED)
Who cites it
103 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Joint Clinical Practice Guideline on Benzodiazepine Tapering: Considerations When Risks Outweigh Benefits.Journal of general internal medicine · 2025Guideline
- Comparative efficacy and safety of daridorexant, lemborexant, and suvorexant for insomnia: a systematic review and network meta-analysis.Translational psychiatry · 2025Pooled it
- Application of a diazepam milligram equivalency algorithm to assess benzodiazepine dose intensity in Rhode Island in 2018.Journal of managed care & specialty pharmacy · 2022Pooled it
- Pooled it
- Fatal intentional drowning in Australia: A systematic literature review of rates and risk factors.PloS one · 2020Pooled it
- Benzodiazepines versus placebo for panic disorder in adults.The Cochrane database of systematic reviews · 2019Pooled it
- A systematic review of interventions to deprescribe benzodiazepines and other hypnotics among older people.European journal of clinical pharmacology · 2017Pooled it
- Effect of discontinuation of lemborexant following long-term treatment of insomnia disorder: Secondary analysis of a randomized clinical trial.Clinical and translational science · 2023Trial
- The effects of music & auditory beat stimulation on anxiety: A randomized clinical trial.PloS one · 2022Trial
- Xenon in the treatment of panic disorder: an open label study.Journal of translational medicine · 2017Trial
- Valproic acid for the management of agitation in neurosurgical intensive care unit patients.Neurocritical care · 2026Article
- Benzodiazepines in Epilepsy: A US Perspective on Clinical Use, Pharmacology, Abuse Methods, and Public Health Considerations.Neurology and therapy · 2026Review
- Tilia Tomentosa promotes sleep, preserving sleep structure.Npj biological timing and sleep · 2026Article
- Incidence and duration of hospital-initiated opioids, benzodiazepines and antipsychotics: a retrospective cohort study.International journal of clinical pharmacy · 2026Article
- Initiation of High-Potency Benzodiazepine Prescriptions Among Survivors of Severe Trauma.Acta anaesthesiologica Scandinavica · 2026Article
- Age and Sex Differences in Alcohol Withdrawal Syndrome.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
- Article
- Cost-utility analysis of benzodiazepine deprescription in primary care: a cohort study.BMC health services research · 2026Article
- Benzodiazepine Dependence: Clinical and Molecular Aspects, Preventive Strategies and Therapeutic Approaches.International journal of molecular sciences · 2026Review
- Management algorithm for alcohol withdrawal syndrome, alcohol dependence (AD) and AD with anxiety in the Indian population: a narrative review with expert opinion.Frontiers in psychiatry · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byBenzodiazepines.2016
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are well-recognised harms from long-term use of benzodiazepines. These include dependency, cognitive decline and falls. It is important to prevent and recognise benzodiazepine dependence. A thorough risk assessment guides optimal management and the necessity for referral. The management of dependence involves either gradual benzodiazepine withdrawal or maintenance treatment. Prescribing interventions, substitution, psychotherapies and pharmacotherapies can all contribute. Unless the patient is elderly, it is helpful to switch to a long-acting benzodiazepine in both withdrawal and maintenance therapy. The dose should be gradually reduced over weeks to lower the risk of seizures. Harms from drugs such as zopiclone and zolpidem are less well characterised. Dependence is managed in the same manner as benzodiazepine dependence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.