Evidence map›Paper›PMID 26648521›Full record

ArticleNature communications2015

Long-term neural and physiological phenotyping of a single human.

Russell A Poldrack, Timothy O Laumann, Oluwasanmi Koyejo, Brenda Gregory, Ashleigh Hover, Mei-Yen Chen, Krzysztof J Gorgolewski, Jeffrey Luci, Sung Jun Joo, Ryan L Boyd and 21 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04748146 (CAUSAL MECHANISMS OF DISTRIBUTED BRAIN NETWORK FUNCTION DURING EPISODIC MEMORY RETRIEVAL), which is not on this map. Cited by 264 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04748146 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Causal mechanisms of distributed brain network function during episodic memory retrieval

TypeinterventionalSponsorNorthwestern UniversityRan2026 to 2027Enrolled0ConditionsEpisodic MemoryArmsBrain stimulation
3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
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204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Russell A PoldrackDepartment of Psychology, University of Texas, Austin, Texas 78712, USA.ORCID http://orcid.org/0000-0001-6755-0259
Timothy O LaumannDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Oluwasanmi KoyejoDepartment of Psychology, Stanford University, Stanford, California 94305, USA.
Brenda GregoryImaging Research Center, University of Texas, Austin, Texas 78712, USA.
Ashleigh HoverImaging Research Center, University of Texas, Austin, Texas 78712, USA.
Mei-Yen ChenDepartment of Psychology, University of Texas, Austin, Texas 78712, USA.
Krzysztof J GorgolewskiDepartment of Psychology, Stanford University, Stanford, California 94305, USA.ORCID http://orcid.org/0000-0003-3321-7583
Jeffrey LuciDepartment of Neuroscience, University of Texas, Austin, Texas 78712, USA.
Sung Jun JooDepartment of Psychology, University of Texas, Austin, Texas 78712, USA.
Ryan L BoydDepartment of Psychology, University of Texas, Austin, Texas 78712, USA.
Scott Hunicke-SmithGenome Sequencing and Analysis Facility, University of Texas, Austin, Texas 78712, USA.ORCID http://orcid.org/0000-0002-3501-8388
Zack Booth SimpsonCenter for Systems and Synthetic Biology, University of Texas, Austin, Texas 78712, USA.
Thomas CavenUniversity Medical Center Brackenridge, Austin, Texas 78701, USA.
Vanessa SochatBiomedical Informatics Program, Stanford University, Stanford, California 94305, USA.ORCID http://orcid.org/0000-0002-4387-3819
James M ShineDepartment of Psychology, Stanford University, Stanford, California 94305, USA.
Evan GordonDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Abraham Z SnyderDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Babatunde AdeyemoDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Steven E PetersenDepartment of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
David C GlahnOlin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06114, USA.
D Reese MckayOlin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06114, USA.
Joanne E CurranSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, Texas 78520, USA.
Harald H H GöringTexas Biomedical Research Institute, San Antonio, Texas 78227, USA.
Melanie A CarlessTexas Biomedical Research Institute, San Antonio, Texas 78227, USA.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, Texas 78520, USA.
Robert DoughertyCenter for Neurobiological Imaging, Stanford University, Stanford, California 94305, USA.
Alexander LeemansImage Sciences Institute, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
Daniel A HandwerkerNational Institute of Mental Health (NIMH), Bethesda, Maryland 20892, USA.
Laurie FrickImaging Research Center, University of Texas, Austin, Texas 78712, USA.
Edward M MarcotteCenter for Systems and Synthetic Biology, University of Texas, Austin, Texas 78712, USA.
Jeanette A MumfordDepartment of Psychology, University of Texas, Austin, Texas 78712, USA.

Funding

Population Research CenterR24HD042849 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI HAYWARD, MARK D. · 2002 to 2016
$8.4M
Genetics of Brain Structure and FunctionR01MH078111 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 2006 to 2014
$4.5M
Genetics of Brain Structure and FunctionR01MH078143 · NIMH · YALE UNIVERSITY · PI GLAHN, DAVID C · 2006 to 2014
$4.3M
Next-Generation Proteomics: Massively Parallel Single-Molecule Protein IdentificaDP1GM106408 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MARCOTTE, EDWARD M · 2012 to 2016
$3.8M
Genetics of Brain Structure and Function: Genome-Wide AssociationR01MH083824 · NIMH · YALE UNIVERSITY · PI GLAHN, DAVID C · 2008 to 2013
$3.3M
Proteomics of widespread, reversible protein assemblies in aging and aggregationR01GM076536 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MARCOTTE, EDWARD M · 2006 to 2014
$2.9M
The Study of Task-Level Control Signals Using fMRIR01NS046424 · NINDS · WASHINGTON UNIVERSITY · PI PETERSEN, STEVEN E. · 2003 to 2006
$1.4M
Dynamics in resting and task-based functional connectivityF30MH100872 · NIMH · WASHINGTON UNIVERSITY · PI LAUMANN, TIMOTHY OTTO · 2013 to 2016
$145k
NICHD NIH HHS 5R24HD042849NICHD NIH HHS R24 HD042849NIGMS NIH HHS DP1 GM106408NIGMS NIH HHS GM076536NIGMS NIH HHS R01 GM076536NIH HHS OD009572NIMH NIH HHS F30 MH100872NIMH NIH HHS MH078111NIMH NIH HHS MH078143NIMH NIH HHS MH083824NIMH NIH HHS MH100872NIMH NIH HHS R01 MH078111NIMH NIH HHS R01 MH078143NIMH NIH HHS R01 MH083824NINDS NIH HHS NS0046424NINDS NIH HHS R01 NS046424
6 · The paper itself

Abstract

Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics. A reproducible analysis workflow is provided, along with open access to the data and an online browser for results. We demonstrate dynamic changes in brain connectivity over the timescales of days to months, and relations between brain connectivity, gene expression and metabolites. This resource can serve as a testbed to study the joint dynamics of human brain and metabolic function over time, an approach that is critical for the development of precision medicine strategies for brain disorders.

Indexed as

Neural PathwaysBrainFollow-Up StudiesGene ExpressionGene Regulatory NetworksHumansMagnetic Resonance ImagingMaleMiddle AgedPhenotypeRadiography

Identifiers

PMID26648521
PMCPMC4682164

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.