Evidence map›Paper›PMID 26648515›Full record

ReviewExpert review of vaccines2016

Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses.

Charles J Russell, Julia L Hurwitz

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of vaccines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
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  6. SERINC5 counters retroviruses and non-retroviruses.Frontiers in cellular and infection microbiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Charles J Russella Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , TN , USA.
Julia L Hurwitza Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , TN , USA.
St. Jude Children's Research Hospital · USUniversity of Tennessee Health Science Center · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GERARD PAUL ZAMBETTI · 1985 to 2026
$166.9M
Recombinant Sendai Virus as Novel Paramyxovirus VaccineP01AI054955 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PORTNER, ALLEN · 2004 to 2008
$3.7M
Influence of maternal antibodies on a Sendai virus-vectored RSV vaccineR01AI088729 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DEVINCENZO, JOHN P., HURWITZ, JULIA L · 2010 to 2014
$3.0M
Molecular basis for parainfluenza virus infection and host responseR01AI083370 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RUSSELL, CHARLES JOHN · 2010 to 2014
$1.9M
NCI NIH HHS NCI P30 CA21765NCI NIH HHS P30 CA021765NIAID NIH HHS P01 AI054955NIAID NIH HHS R01 AI083370NIAID NIH HHS R01 AI088729PHS HHS NIH NIAID R01 AI088729
6 · The paper itself

Abstract

Human paramyxoviruses are the etiological agents for life-threatening respiratory virus infections of infants and young children. These viruses, including respiratory syncytial virus (RSV), the human parainfluenza viruses (hPIV1-4) and human metapneumovirus (hMPV), are responsible for millions of serious lower respiratory tract infections each year worldwide. There are currently no standard treatments and no licensed vaccines for any of these pathogens. Here we review research with which Sendai virus, a mouse parainfluenza virus type 1, is being advanced as a Jennerian vaccine for hPIV1 and as a backbone for RSV, hMPV and other hPIV vaccines for children.

Indexed as

Drug CarriersGenetic VectorsAnimalsDrug DiscoveryHumansParamyxoviridae InfectionsRespiratory Syncytial Virus InfectionsRespirovirus InfectionsSendai virusViral VaccinesDrug CarriersViral Vaccinesantibodyintranasalparamyxoviruspediatric vaccinerespiratory tractSendai virusT cellvaccine vector

Identifiers

PMID26648515
PMCPMC4957581
OpenAlexW2214853820

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.