ArticleScientific reports2015
A competitive photoelectrochemical immunosensor based on a CdS-induced signal amplification strategy for the ultrasensitive detection of dexamethasone.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 33 citations in OpenAlex.
- A proposed implantable voltammetric carbon fiber-based microsensor for corticosteroid monitoring by cochlear implants.Mikrochimica acta · 2021Article
- Cellulose acetate beads modified with cadmium sulfide and Methylene blue for adsorbent-assisted photoelectrochemical detection of copper(II) ions.Mikrochimica acta · 2019Article
- Selection of high affinity aptamer-ligand for dexamethasone and its electrochemical biosensor.Scientific reports · 2019Article
- A photoelectrochemical sandwich immunoassay for protein S100β, a biomarker for Alzheimer's disease, using an ITO electrode modified with a reduced graphene oxide-gold conjugate and CdS-labeled secondary antibody.Mikrochimica acta · 2019Article
- Visible-light driven Photoelectrochemical Immunosensor Based on SnSScientific reports · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
A novel photoelectrochemical immunosensor based on the competitive strategy is proposed for the specific detection of dexamethasone (DXM). Graphitic carbon nitride coupled with bismuth sulfide are used as the sensing matrix for the immobilization of BSA-DXM on the electrode surface, while cadmium sulfide functionalized titanium dioxide (TiO2@CdS) is used as the photoelectric active labels of anti-DXM. Due to the perfect matching of energy levels between TiO2 and CdS, the in situ prepared composite labels show excellent photocurrent response under visible lights. The competitive binding of DXM in sample solutions and BSA-DXM on the electrode surface reduces the specific attachment of labels to the electrode, resulting in a decrease of the photocurrent intensity. Greatly enhanced sensitivity is achieved after the optimization of the detection conditions. Under the optimal detection condition, the well-designed immunosensor for DXM exhibits a low detection limit of 2 pg ∙ mL(-1). Additionally, the proposed immunoassay system shows high specificity, good reproducibility and acceptable stability, which is also expected to become a promising platform for the detection of other small molecules.
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