ArticleScientific reports2015
Simulation of avascular tumor growth by agent-based game model involving phenotype-phenotype interactions.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Matrigel-embedded 3D culture maintains stemness and enhances hair-inductive capacity of human hair follicle epithelial stem cells.Regenerative therapy · 2026Article
- A missed synthesis from the 1930s: Teorell, Mayneord, and the origins of physiological PK-TGI modelling.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- SISTEM: simulation of tumor evolution, metastasis, and DNA-seq data under genotype-driven selection.Bioinformatics (Oxford, England) · 2025Article
- Using spatial statistics to infer game-theoretic interactions in an agent-based model of cancer cells.bioRxiv : the preprint server for biology · 2025Article
- Mimicking the Complexity of Solid Tumors: How Spheroids Could Advance Cancer Preclinical Transformative Approaches.Cancers · 2025Article
- Agent-based modeling in cancer biomedicine: applications and tools for calibration and validation.Cancer biology & therapy · 2024Review
- Comparing mechanism-based and machine learning models for predicting the effects of glucose accessibility on tumor cell proliferation.Scientific reports · 2023Article
- Modeling cancer's ecological and evolutionary dynamics.Medical oncology (Northwood, London, England) · 2023Article
- A multi-layered hybrid model for cancer cell invasion.Medical & biological engineering & computing · 2022Article
- The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer.Dynamic games and applications · 2022Review
- Article
- An experimental-mathematical approach to predict tumor cell growth as a function of glucose availability in breast cancer cell lines.PloS one · 2021Article
- Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors.PLoS computational biology · 2018Article
- Mathematical Modeling of the Function of Warburg Effect in Tumor Microenvironment.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All tumors, both benign and metastatic, undergo an avascular growth stage with nutrients supplied by the surrounding tissue. This avascular growth process is much easier to carry out in more qualitative and quantitative experiments starting from tumor spheroids in vitro with reliable reproducibility. Essentially, this tumor progression would be described as a sequence of phenotypes. Using agent-based simulation in a two-dimensional spatial lattice, we constructed a composite growth model in which the phenotypic behavior of tumor cells depends on not only the local nutrient concentration and cell count but also the game among cells. Our simulation results demonstrated that in silico tumors are qualitatively similar to those observed in tumor spheroid experiments. We also found that the payoffs in the game between two living cell phenotypes can influence the growth velocity and surface roughness of tumors at the same time. Finally, this current model is flexible and can be easily extended to discuss other situations, such as environmental heterogeneity and mutation.
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