ArticleSao Paulo medical journal = Revista paulista de medicina
Down syndrome: Prevalence and distribution of congenital heart disease in Brazil.
Article in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Gender differences in the prevalence of congenital heart disease in Down's syndrome: a brief meta-analysis.BMC medical genetics · 2017Pooled it
- Trial
- Patterns, survival, and mortality predictors in children with down syndrome and congenital heart disease in resource-limited settings: a follow-up study.BMC pediatrics · 2026Article
- Congenital heart diseases: population-based cross-sectional study and spatial analysis, São Paulo, 2012-2022.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
- Isolated pulmonary valve endocarditis in a pediatric patient with down syndrome.Journal of cardiothoracic surgery · 2024Article
- Nationwide hospitalizations of patients with down syndrome and congenital heart disease over a 15-year period.European journal of pediatrics · 2024Article
- Human Genetics of Congenital Heart Defects.Advances in experimental medicine and biology · 2024Review
- Analysis of Down syndrome newborn outcomes in three neonatal intensive care units in Rio de Janeiro, Brazil.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Unraveling Down Syndrome: From Genetic Anomaly to Artificial Intelligence-Enhanced Diagnosis.Biomedicines · 2023Review
- Congenital Heart Defects and Outcome in a Large Cohort of Down Syndrome: A Single-Center Experience from Turkey.Turkish archives of pediatrics · 2023Article
- Cardiovascular Complications of Down Syndrome: Scoping Review and Expert Consensus.Circulation · 2023Article
- Risk for Severe Illness and Death among Pediatric Patients with Down Syndrome Hospitalized for COVID-19, Brazil.Emerging infectious diseases · 2023Article
- Maternal Risk Factors Triggering Congenital Heart Defects in Down Syndrome: A Case-Control Study.Pediatric reports · 2022Article
- Willingness to Pay for Down Syndrome Screening: A systematics Review.Medical journal of the Islamic Republic of Iran · 2022Review
- Prevalence of pulmonary hypertension among children with Down syndrome: A systematic review and meta-analysis.World journal of clinical pediatrics · 2021Article
- Congenital heart defects among Down's syndrome cases: an updated review from basic research to an emerging diagnostics technology and genetic counselling.Journal of genetics · 2021Review
- Memorization of daily routines by children with Down syndrome assisted by a playful virtual environment.Scientific reports · 2020Article
- Article
- [Congenital heart disease associated with the most prevalent chromosomal syndromes: a literature review].Archivos peruanos de cardiologia y cirugia cardiovascularReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CONTEXT AND
objectiveDown syndrome is the most common genetic disorder, affecting 1/700 live births. Among the clinical findings, one constant concern is the high prevalence of congenital heart disease. The objective of this study was to determine the prevalence and profile of congenital heart disease among patients attended at a Down syndrome outpatient clinic in southern Brazil between 2005 and 2013. DESIGN AND
settingCross-sectional study conducted in a referral center.
methodsData were retrospectively gathered from the medical files of 1,207 patients with Down syndrome, among whom 604 (50.0%) had been diagnosed with congenital heart disease. These data were subjected to descriptive analysis using the Statistica software.
resultsAmong the 604 patients with congenital heart disease, 338 (55.8%) were male and 269 (44.5%) were female. The most common heart diseases were atrial septal defect in 254 patients (42.1%); total atrioventricular septal defect in 91 (15.1%); atrial septal defect and ventricular septal defect in 88 (14.6%); ventricular septal defect in 77 (12.7%); patent ductus arteriosus in 40 (6.6%); patent foramen ovale in 34 (5.6%) patients; tetralogy of Fallot in 12 (2%); and other diseases in 8 (1.3%). Pulmonary hypertension was present in 57 (9.4%). Out of the total, 150 patients (24.8%) underwent cardiac surgery.
conclusionThe high prevalence of congenital heart disease among the patients at the Down syndrome outpatient clinic (50%) was similar to findings from other studies and justifies investigation during the neonatal period, so as to decrease mortality and morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.