ArticleDevelopment and psychopathology2016
The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence.
Article in Development and psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Brain circuitry, behavior, and cognition: A randomized placebo-controlled trial of donepezil in fragile X syndrome.Journal of psychopharmacology (Oxford, England) · 2019Trial
- [Neurocognitive profile and vulnerability for mental health problems in selected genetic syndromes with disorders of intellectual development].Der Nervenarzt · 2026Review
- Aberrant neural activation during inhibitory control in girls with fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Similar Gap-Overlap Profiles in Children with Fragile X Syndrome and IQ-Matched Autism.Journal of autism and developmental disorders · 2025Article
- Cognition, academic achievement, and adaptive behavior in school-aged girls with fragile X syndrome.Research in developmental disabilities · 2023Article
- Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals.Cells · 2023Article
- Neuroanatomical Profile of Young Females with Fragile X Syndrome: A Voxel-Based Morphometry Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Glucocorticoid regulation and neuroanatomy in fragile x syndrome.Journal of psychiatric research · 2021Article
- Developmental studies in fragile X syndrome.Journal of neurodevelopmental disorders · 2020Review
- Intellectual functioning and behavioural features associated with mosaicism in fragile X syndrome.Journal of neurodevelopmental disorders · 2019Article
- Executive Function in Fragile X Syndrome: A Systematic Review.Brain sciences · 2019Review
- Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features.Molecular autism · 2019Article
- Neuroanatomical abnormalities in fragile X syndrome during the adolescent and young adult years.Journal of psychiatric research · 2018Article
- Longitudinal identification of clinically distinct neurophenotypes in young children with fragile X syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Updated report on tools to measure outcomes of clinical trials in fragile X syndrome.Journal of neurodevelopmental disorders · 2017Review
- Working memory and arithmetic impairments in children with FMR1 premutation and gray zone alleles.Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Few studies have investigated developmental strengths and weaknesses within the cognitive profile of children and adolescents with fragile X syndrome (FXS), a single-gene cause of inherited intellectual impairment. With a prospective longitudinal design and using normalized raw scores (Z scores) to circumvent floor effects, we measured cognitive functioning of 184 children and adolescents with FXS (ages 6 to 16) using the Wechsler Scale of Intelligence for Children on one to three occasions for each participant. Participants with FXS received lower raw scores relative to the Wechsler Scale of Intelligence for Children normative sample across the developmental period. Verbal comprehension, perceptual organization, and processing speed Z scores were marked by a widening gap from the normative sample, while freedom from distractibility Z scores showed a narrowing gap. Key findings include a relative strength for verbal skills in comparison with visuospatial-constructive skills arising in adolescence and a discrepancy between working memory (weakness) and processing speed (strength) in childhood that diminishes in adolescence. Results suggest that the cognitive profile associated with FXS develops dynamically from childhood to adolescence. Findings are discussed within the context of aberrant brain morphology in childhood and maturation in adolescence. We argue that assessing disorder-specific cognitive developmental profiles will benefit future disorder-specific treatment research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.