ArticleJournal of biosciences2015
In search of principles for a Theory of Organisms.
Article in Journal of biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Modeling Mammary Organogenesis from Biological First Principles: A Systems Biology Approach.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Towards modelling emergence in plant systems.Quantitative plant biology · 2023Article
- A computational model of organism development and carcinogenesis resulting from cells' bioelectric properties and communication.Scientific reports · 2022Article
- Always Pay Attention to Which Model of Motor Learning You Are Using.International journal of environmental research and public health · 2022Review
- A Generative View of Rationality and Growing AwarenessFrontiers in psychology · 2022Article
- The cancer puzzle: Welcome to organicism.Progress in biophysics and molecular biology · 2021Article
- A bioelectric model of carcinogenesis, including propagation of cell membrane depolarization and reversal therapies.Scientific reports · 2021Article
- Six 'Must-Have' Minerals for Life's Emergence: Olivine, Pyrrhotite, Bridgmanite, Serpentine, Fougerite and Mackinawite.Life (Basel, Switzerland) · 2020Article
- Over a century of cancer research: Inconvenient truths and promising leads.PLoS biology · 2020Article
- Order Through Disorder: The Characteristic Variability of Systems.Frontiers in cell and developmental biology · 2020Review
- Second-Generation Digital Health Platforms: Placing the Patient at the Center and Focusing on Clinical Outcomes.Frontiers in digital health · 2020Article
- Glycemia Regulation: From Feedback Loops to Organizational Closure.Frontiers in physiology · 2020Article
- Personalized inherent randomness of the immune system is manifested by an individualized response to immune triggers and immunomodulatory therapies: a novel platform for designing personalized immunotherapies.Immunologic research · 2019Article
- Primary Immunodeficiency and Cancer Predisposition Revisited: Embedding Two Closely Related Concepts Into an Integrative Conceptual Framework.Frontiers in immunology · 2018Review
- An Integrative Approach Toward Biology, Organisms, and Cancer.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Toward a theory of organisms: Three founding principles in search of a useful integration.Progress in biophysics and molecular biology · 2016Review
- Why do we need theories?Progress in biophysics and molecular biology · 2016Review
- Carcinogenesis explained within the context of a theory of organisms.Progress in biophysics and molecular biology · 2016Review
- The biological default state of cell proliferation with variation and motility, a fundamental principle for a theory of organisms.Progress in biophysics and molecular biology · 2016Review
- Modeling mammary organogenesis from biological first principles: Cells and their physical constraints.Progress in biophysics and molecular biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Lacking an operational theory to explain the organization and behaviour of matter in unicellular and multicellular organisms hinders progress in biology. Such a theory should address life cycles from ontogenesis to death. This theory would complement the theory of evolution that addresses phylogenesis, and would posit theoretical extensions to accepted physical principles and default states in order to grasp the living state of matter and define proper biological observables. Thus, we favour adopting the default state implicit in Darwin's theory, namely, cell proliferation with variation plus motility, and a framing principle, namely, life phenomena manifest themselves as non-identical iterations of morphogenetic processes. From this perspective, organisms become a consequence of the inherent variability generated by proliferation, motility and self-organization. Morphogenesis would then be the result of the default state plus physical constraints, like gravity, and those present in living organisms, like muscular tension.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.