ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Estradiol in the Preoptic Area Regulates the Dopaminergic Response to Cocaine in the Nucleus Accumbens.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 82 citations in OpenAlex.
- Dose-dependent effects of estrogen on prediction error related neural activity in the nucleus accumbens of healthy young women.Psychopharmacology · 2020Trial
- Direct Intra-Accumbens 17 Beta-Estradiol Administration Increases Voluntary Wheel Running in Ovariectomized Rats.Neuroendocrinology · 2026Article
- Reduced sensitivity to cocaine effects and changes in mesocorticolimbic dopamine receptors in adolescent sexually active female rats.Psychopharmacology · 2025Article
- Postoperative sepsis-associated neurocognitive disorder: mechanisms, predictive strategies, and treatment approaches.Frontiers in medicine · 2025Review
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- The impact of estradiol on serotonin, glutamate, and dopamine systems.Frontiers in neuroscience · 2024Review
- Neurosteroids and the mesocorticolimbic system.Neuroscience and biobehavioral reviews · 2023Review
- Distinct patterns of gene expression in the medial preoptic area are related to gregarious singing behavior in European starlings (Sturnus vulgaris).BMC neuroscience · 2023Article
- The importance of translationally evaluating steroid hormone contributions to substance use.Frontiers in neuroendocrinology · 2023Review
- Estrous Cycle Mediates Midbrain Neuron Excitability Altering Social Behavior upon Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The medial preoptic area and acute cocaine's stimulant effects in rats: Potential influences of estradiol and biological sex.Hormones and behavior · 2023Article
- Sex Steroid Hormone Receptor Content of Medial Preoptic Efferents to the Ventral Tegmental Area Is Sexually Dimorphic: Implications for Sex Differences in Mesolimbic Reward Processing.Neuroendocrinology · 2023Article
- Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward.International journal of molecular sciences · 2022Review
- Effects of early life adversity on male reproductive behavior and the medial preoptic area transcriptome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Membrane estrogen signaling in female reproduction and motivation.Frontiers in endocrinology · 2022Review
- Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.Psychopharmacology · 2021Article
- The Role of Beta-Endorphin in Cocaine-Induced Conditioned Place Preference, Its Extinction, and Reinstatement in Male and Female Mice.Frontiers in behavioral neuroscience · 2021Article
- The effects of early life stress on motivated behaviors: A role for gonadal hormones.Neuroscience and biobehavioral reviews · 2020Review
- Sexual Differentiation and Substance Use: A Mini-Review.Endocrinology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
The sex-steroid hormone estradiol (E2) enhances the psychoactive effects of cocaine, as evidenced by clinical and preclinical studies. The medial preoptic area (mPOA), a region in the hypothalamus, is a primary neural locus for neuroendocrine integration, containing one of the richest concentrations of estrogen receptors in the CNS and also has a key role in the regulation of naturally rewarding behaviors. However, whether estradiol enhances the neurochemical response to cocaine by acting in the mPOA is still unclear. Using neurotoxic lesions and microdialysis, we examined whether the mPOA modulates cocaine-induced neurochemical activity in the nucleus accumbens. Tract tracing and immunohistochemical staining were used to determine whether projections from the mPOA to the ventral tegmental area (VTA) are sensitive to estrogen signaling. Finally, estradiol microinjections followed by microdialysis were used to determine whether estrogenic signaling in the mPOA modulates cocaine-induced changes of dopamine in the nucleus accumbens. Results showed that lesions of the mPOA or microinjections of estradiol directly into the mPOA increased cocaine-induced release of dopamine in the nucleus accumbens. Immunohistochemical analyses revealed that the mPOA modulates cocaine responsiveness via projections to both dopaminergic and GABAergic neurons in the VTA, and that these projections are sensitive to estrogenic stimulation. Taken together, these findings point to a novel estradiol-dependent pathway that modulates cocaine-induced neurochemical activity in the mesolimbic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.