Evidence map›Paper›PMID 26647745›Full record

ArticleBrazilian journal of physical therapy

Interval training based on ventilatory anaerobic threshold increases cardiac vagal modulation and decreases high-sensitivity c-reative protein: randomized clinical trial in coronary artery disease.

Nayara Y Tamburus, Roberta F L Paula, Vandeni C Kunz, Marcelo C César, Marlene A Moreno, Ester da Silva

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03121911 (Effects of Interval Physical Training on Inflammatory Markers, Cardiac Autonomic Modulation at Rest, Expiratory Flow Limitation and Respiratory Efficiency in Recent Myocardial Infarction), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03121911 nawithdrawnnot on this map

Effects of Interval Physical Training on Inflammatory Markers, Cardiac Autonomic Modulation at Rest, Expiratory Flow Limitation and Respiratory Efficiency in Recent Myocardial Infarction

TypeinterventionalSponsorFederal University of UberlandiaRan2019 to 2022Enrolled0ConditionsExpiratory Flow Limitation, Recent Myocardial InfarctionArmsInterval Training (IT), Inspiratory Muscle Training (IMT)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nayara Y TamburusDepartamento de Fisioterapia, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
Roberta F L PaulaFaculdade de Ciências da Saúde, Universidade Metodista de Piracicaba, Piracicaba, SP, Brazil.
Vandeni C KunzCentro Universitário Adventista, Engenheiro Coelho, SP, Brazil.
Marcelo C CésarFaculdade de Ciências da Saúde, UNIMEP, Piracicaba, SP, Brazil.
Marlene A MorenoFaculdade de Ciências da Saúde, Universidade Metodista de Piracicaba, Piracicaba, SP, Brazil.
Ester da SilvaDepartamento de Fisioterapia, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
Methodist University of Piracicaba · BRUniversidade Federal de São Carlos · BRCentro Universitário Adventista de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutonomic dysfunction and inflammatory activity are involved in the development and progression of coronary artery disease (CAD), and exercise training has been shown to confer a cardiovascular benefit.

objectiveTo evaluate the effects that interval training (IT) based on ventilatory anaerobic threshold (VAT) has on heart rate variability (HRV) and high-sensitivity C-reactive protein (hs-CRP) levels, as well as the relationship between both levels, in patients with CAD and/or cardiovascular risk factors (RF).

methodForty-two men (aged 57.88±6.20 years) were divided into two training groups, CAD-T (n= 12) and RF-T (n= 10), and two control groups, CAD-C (n= 10) and RF-C (n=10). Heart rate and RR intervals in the supine position, cardiopulmonary exercise tests, and hs-CRP levels were measured before and after IT. HRV was analyzed by spectral and symbolic analysis. The CAD-T and RF-T underwent a 16-week IT program of three weekly sessions at training intensities based on the VAT.

resultsIn the RF-T, cardiac sympathetic modulation index and hs-CRP decreased (p<0.02), while cardiac parasympathetic modulation index increased (p<0.02). In the CAD-T, cardiac parasympathetic modulation index increased, while hs-CRP, systolic, and diastolic blood pressures decreased (p<0.02). Both control groups showed increase in hs-CRP parameters (p<0.02). There was a strong and significant association between parasympathetic and sympathetic modulations with hs-CRP.

conclusionThe IT program based on the VAT promoted a decrease in hs-CRP associated with improvement in cardiac autonomic modulation.

Indexed as

Anaerobic ThresholdBlood PressureCardiovascular DiseasesCoronary Artery DiseaseC-Reactive ProteinHeart RateHumansTreatment OutcomeVagus NerveVagus Nerve StimulationC-Reactive Protein

Identifiers

PMID26647745
PMCPMC4668337
OpenAlexW2177204862

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.