Evidence map›Paper›PMID 26647717›Full record

ArticleMucosal immunology2016

Induction of partial immunity in both males and females is sufficient to protect females against sexual transmission of Chlamydia.

C P O'Meara, C W Armitage, A Kollipara, D W Andrew, L Trim, M B Plenderleith, K W Beagley

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Multi-component prime-boostFrontiers in immunology · 2022
    Article
  9. Article
  10. Expert review of vaccines · 2021
    Article
  11. Article
  12. Article
  13. Detection of chlamydia infection within human testicular biopsies.Human reproduction (Oxford, England) · 2019
    Article
  14. Review
  15. Article
  16. Article
  17. Update on Chlamydia trachomatis Vaccinology.Clinical and vaccine immunology : CVI · 2017
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

C P O'MearaDepartment of Infectious Diseases, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
C W ArmitageDepartment of Infectious Diseases, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
A KolliparaDepartment of Infectious Diseases, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
D W AndrewDepartment of Infectious Diseases, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
L TrimDepartment of Infectious Diseases, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
M B PlenderleithDepartment of Biomedical Sciences, Neuroscience Laboratory-School of Biomedical Science, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
K W BeagleyDepartment of Infectious Diseases, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Queensland University of Technology · AUBurnet Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sexually transmitted Chlamydia trachomatis causes infertility, and because almost 90% of infections are asymptomatic, a vaccine is required for its eradication. Mathematical modeling studies have indicated that a vaccine eliciting partial protection (non-sterilizing) may prevent Chlamydia infection transmission, if administered to both sexes before an infection. However, reducing chlamydial inoculum transmitted by males and increasing infection resistance in females through vaccination to elicit sterilizing immunity has yet to be investigated experimentally. Here we show that a partially protective vaccine (chlamydial major outer membrane protein (MOMP) and ISCOMATRIX (IMX) provided sterilizing immunity against sexual transmission between immunized mice. Immunizing male or female mice before an infection reduced chlamydial burden and disease development, but did not prevent infection. However, infection and inflammatory disease responsible for infertility were absent in 100% of immunized female mice challenged intravaginally with ejaculate collected from infected immunized males. In contrast to the sterilizing immunity generated following recovery from a previous chlamydial infection, protective immunity conferred by MOMP/IMX occurred independent of resident memory T cells. Our results demonstrate that vaccination of males or females can further protect the opposing sex, whereas vaccination of both sexes can synergize to elicit sterilizing immunity against Chlamydia sexual transmission.

Indexed as

AnimalsBacterial LoadBacterial Outer Membrane ProteinsBacterial VaccinesCells, CulturedChlamydia InfectionsChlamydia muridarumCholesterolDisease Models, AnimalDrug CombinationsFemaleHumansImmunityImmunologic MemoryMaleMiceBacterial Outer Membrane ProteinsBacterial VaccinesCholesterolDrug CombinationsISCOMATRIXmajor outer membrane protein, Chlamydia pneumoniaePhospholipidsSaponins

Identifiers

PMID26647717
OpenAlexW2423605586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.