ArticleMolecular systems biology2015
Olfactory sensory neurons transiently express multiple olfactory receptors during development.
Article in Molecular systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed, 187 citations in OpenAlex.
- Immature olfactory sensory neurons provide complementary input in the intact olfactory system.iScience · 2026Article
- Systematic benchmarking of ambient RNA decontamination tools to advance precision in single-cell transcriptomic analysis.Nature communications · 2026Article
- A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain.Cell · 2026Article
- Non-uniform endogenous regeneration of olfactory sensory neuron axons across the mouse olfactory bulb.Scientific reports · 2026Article
- Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung.Journal of leukocyte biology · 2026Article
- Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026Article
- Delta family protocadherins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb.PLoS genetics · 2026Article
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior.Nature communications · 2025Article
- Article
- DeCoST: unveiling cell type heterogeneity in spatial transcriptomics based on inter-domain alignment and Gaussian kernel conditional autoregressive.Briefings in bioinformatics · 2025Article
- Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity.Cell reports · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Article
- Quiescent horizontal basal stem cells act as a niche for olfactory neurogenesis in a mouse 3D organoid model.Cell reports methods · 2025Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance.Nature microbiology · 2025Article
- Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe.Current opinion in genetics & development · 2025Review
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In mammals, each olfactory sensory neuron randomly expresses one, and only one, olfactory receptor (OR)--a phenomenon called the "one-neuron-one-receptor" rule. Although extensively studied, this rule was never proven for all ~1,000 OR genes in one cell at once, and little is known about its dynamics. Here, we directly tested this rule by single-cell transcriptomic sequencing of 178 cells from the main olfactory epithelium of adult and newborn mice. To our surprise, a subset of cells expressed multiple ORs. Most of these cells were developmentally immature. Our results illustrated how the "one-neuron-one-receptor" rule may have been established: At first, a single neuron temporarily expressed multiple ORs--seemingly violating the rule--and then all but one OR were eliminated. This work provided experimental evidence that epigenetic regulation in the olfactory system selects a single OR by suppressing a few transiently expressed ORs in a single cell during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.