ReviewSocial psychiatry and psychiatric epidemiology2016
The ROOTS study: a 10-year review of findings on adolescent depression, and recommendations for future longitudinal research.
Review in Social psychiatry and psychiatric epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Interpretation biases in child and youth depression: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Review
- The mediating role of cognitive schemas in the relationship between parenting styles and suicidal ideation in adolescents: a structural equation modeling approach.BMC research notes · 2025Article
- Early adolescent perceived friendship quality aids affective and neural responses to social inclusion and exclusion in young adults with and without adverse childhood experiences.Social cognitive and affective neuroscience · 2024Article
- Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences.Frontiers in neuroendocrinology · 2024Review
- Retrospective analysis of clinical characteristics and treatment of children and adolescents with depression.Frontiers in psychiatry · 2023Article
- Behavioral measures of impulsivity and compulsivity in adolescents with nonsuicidal self-injury.CNS spectrums · 2022Article
- Device-measured sleep onset and duration in the development of depressive symptoms in adolescence.Journal of affective disorders · 2022Article
- Mental Health and Wellbeing in Young People in the UK during Lockdown (COVID-19).International journal of environmental research and public health · 2022Article
- The Potential for Outdoor Nature-Based Interventions in the Treatment and Prevention of Depression.Frontiers in psychology · 2022Review
- Participants Attrition in a Longitudinal Study: The Malaysian Cohort Study Experience.International journal of environmental research and public health · 2021Article
- The interplay between adolescent friendship quality and resilient functioning following childhood and adolescent adversity.Adversity and resilience science · 2021Article
- Predictors of Attrition in Longitudinal Neuroimaging Research: Inhibitory Control, Head Movement, and Resting-State Functional Connectivity.Brain connectivity · 2018Article
- Diet quality and depressive symptoms in adolescence: no cross-sectional or prospective associations following adjustment for covariates.Public health nutrition · 2018Article
- Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- The association between pubertal status and depressive symptoms and diagnoses in adolescent females: A population-based cohort study.PloS one · 2018Article
- Novel methods in psychiatric epidemiology.Social psychiatry and psychiatric epidemiology · 2016Article
- The importance of developmental mechanisms in understanding adolescent depression.Social psychiatry and psychiatric epidemiology · 2016Article
- Friendships and Family Support Reduce Subsequent Depressive Symptoms in At-Risk Adolescents.PloS one · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of this study is to review longitudinal findings on adolescent mental health from the 'ROOTS study', and provide directions and recommendations for future longitudinal research. To do this, we discuss relevant findings from the ROOTS study, and review its strengths and limitations.
methodsWe examined all publications from the ROOTS study up to July 2015, selected those examining adolescent mental health, and classified them as investigating (a) childhood risk factors for adolescent depression, (b) genetic and cognitive vulnerability to depression in adolescence, (c) genetic markers, childhood adversities, and neuroendophenotypes, (d) morning cortisol and depression, (e) physical activity and depression symptoms, and (f) the underlying structure of mental health in adolescence. We reviewed the strengths and limitations of the ROOTS study, and how they feed into recommendations for future longitudinal research.
resultsThere was evidence supporting a putative hormonal biomarker for the emergence of depression in boys. Environmental pathways from child adversity to adolescent depression were confirmed in girls, partly accounted for by negative life events in early adolescence. The preceding role of automatic cognitive biases assessed using behavioural tasks was substantiated, with evidence for genetic susceptibility. Novel latent statistical models of child adversity, depression, anxiety, and psychotic experiences were produced, with concurrent and prospective validity. Our experiences conducting the ROOTS study resulted in a set of strengths, limitations, and recommendations for future longitudinal studies.
conclusionsThe ROOTS study has advanced knowledge on the aetiology of adolescent depression by investigating environmental, genetic, hormonal, and neural risk factors. Findings provide a foundation for future research integrating cognitive neuroscience with epidemiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.