Evidence map›Paper›PMID 26646793›Full record

ArticleOncotarget2015

Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.

Kyle M Walsh, Veryan Codd, Terri Rice, Christopher P Nelson, Ivan V Smirnov, Lucie S McCoy, Helen M Hansen, Edward Elhauge, Juhi Ojha, Stephen S Francis and 14 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 9 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 9 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 2 countries.

Kyle M WalshDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Veryan CoddDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Terri RiceDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Ivan V SmirnovDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Lucie S McCoyDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Helen M HansenDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Edward ElhaugeDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Juhi OjhaDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Stephen S FrancisDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Nils R MadsenDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco , California, USA.
Alexander R PicoGladstone Institutes, San Francisco, California, USA.
Annette M MolinaroDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Tarik TihanDepartment of Pathology, University of California, San Francisco, San Francisco, California, USA.
Mitchel S BergerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Susan M ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Michael D PradosDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Joseph L WiemelsDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
ENGAGE Consortium Telomere Group
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
John K WienckeDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Margaret R WrenschDivision of Neuroepidemiology, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USNeurological Surgery · USUniversity of Leicester · GBGladstone Institutes · USGlenfield Hospital · GBMayo Clinic · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Targeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK · 2004 to 2015
$22.5M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5M
Biomarkers of survival in glioma epidemiologyR01CA126831 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2008 to 2013
$2.5M
Identification of 9p and 20q Germline Alterations in Glioblastoma PathogenesisRC1NS068222 · NINDS · MAYO CLINIC ROCHESTER · PI JENKINS, ROBERT B. · 2009 to 2010
$984k
British Heart FoundationMedical Research Council MR/M012816/1NCCDPHP CDC HHS U58 DP003862NCCDPHP CDC HHS U58DP003862-01NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS P30 CA015083NCI NIH HHS P30CA15083NCI NIH HHS P50 CA097257NCI NIH HHS P50CA097257NCI NIH HHS P50 CA108961NCI NIH HHS P50CA108961NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA126831NCI NIH HHS R01CA126831NCI NIH HHS R01 CA139020NCI NIH HHS R01CA139020NCI NIH HHS R01CA52689NCI NIH HHS R25 CA112355NCI NIH HHS R25CA112355NCI NIH HHS T32 CA151022NCRR NIH HHS UL1 RR024131NINDS NIH HHS RC1 NS068222NINDS NIH HHS RC1NS068222ZWellcome TrustWellcome Trust 076113Wellcome Trust 085475
6 · The paper itself

Abstract

Telomere maintenance has emerged as an important molecular feature with impacts on adult glioma susceptibility and prognosis. Whether longer or shorter leukocyte telomere length (LTL) is associated with glioma risk remains elusive and is often confounded by the effects of age and patient treatment. We sought to determine if genotypically-estimated LTL is associated with glioma risk and if inherited single nucleotide polymorphisms (SNPs) that are associated with LTL are glioma risk factors. Using a Mendelian randomization approach, we assessed differences in genotypically-estimated relative LTL in two independent glioma case-control datasets from the UCSF Adult Glioma Study (652 patients and 3735 controls) and The Cancer Genome Atlas (478 non-overlapping patients and 2559 controls). LTL estimates were based on a weighted linear combination of subject genotype at eight SNPs, previously associated with LTL in the ENGAGE Consortium Telomere Project. Mean estimated LTL was 31bp (5.7%) longer in glioma patients than controls in discovery analyses (P = 7.82x10-8) and 27bp (5.0%) longer in glioma patients than controls in replication analyses (1.48x10-3). Glioma risk increased monotonically with each increasing septile of LTL (O.R.=1.12; P = 3.83x10-12). Four LTL-associated SNPs were significantly associated with glioma risk in pooled analyses, including those in the telomerase component genes TERC (O.R.=1.14; 95% C.I.=1.03-1.28) and TERT (O.R.=1.39; 95% C.I.=1.27-1.52), and those in the CST complex genes OBFC1 (O.R.=1.18; 95% C.I.=1.05-1.33) and CTC1 (O.R.=1.14; 95% C.I.=1.02-1.28). Future work is needed to characterize the role of the CST complex in gliomagenesis and further elucidate the complex balance between ageing, telomere length, and molecular carcinogenesis.

Indexed as

AdultBrain NeoplasmsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGliomaHumansLeukocytesMaleModels, StatisticalPolymorphism, Single NucleotideRisk FactorsTelomereCST complexgliomasingle nucleotide polymorphismtelomerasetelomere

Identifiers

PMID26646793
PMCPMC4767445
OpenAlexW2193901525

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.