ArticleEuropean journal of nuclear medicine and molecular imaging2016
Reproducibility of O-(2-(18)F-fluoroethyl)-L-tyrosine uptake kinetics in brain tumors and influence of corticoid therapy: an experimental study in rat gliomas.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- A prospective clinical study of the influence of oral protein intake on [EJNMMI research · 2024Article
- Review
- An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems.EJNMMI physics · 2020Article
- High uptake ofEJNMMI research · 2020Article
- Influence of Dexamethasone on O-(2-[Molecular imaging and biology · 2019Article
- Article
- Evaluation of factors influencingNeuroImage. Clinical · 2018Article
- Influence of blood-brain barrier permeability on O-(2-European journal of nuclear medicine and molecular imaging · 2017Article
- Utility of FET-PET in detecting high-grade gliomas presenting with equivocal MR imaging features.World journal of nuclear medicineArticle
- A systematic review of amino acid PET in assessing treatment response to temozolomide in glioma.Neuro-oncology advancesReview
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9 authors at 3 institutions in 1 country.
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Abstract
purposePositron emission tomography (PET) using O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) is a well-established method for the diagnostics of brain tumors. This study investigates reproducibility of (18)F-FET uptake kinetics in rat gliomas and the influence of the frequently used dexamethasone (Dex) therapy.
methodsF98 glioma or 9L gliosarcoma cells were implanted into the striatum of 31 Fischer rats. After 10-11 days of tumor growth, the animals underwent dynamic PET after injection of (18)F-FET (baseline). Thereafter, animals were divided into a control group and a group receiving Dex injections, and all animals were reinvestigated 2 days later. Tumor-to-brain ratios (TBR) of (18)F-FET uptake (18-61 min p.i.) and the slope of the time-activity-curves (TAC) (18-61 min p.i.) were evaluated using a Volume-of-Interest (VOI) analysis. Data were analyzed by two-way repeated measures ANOVA and reproducibility by the intraclass correlation coefficient (ICC).
resultsThe slope of the tumor TACs showed high reproducibility with an ICC of 0.93. A systematic increase of the TBR in the repeated scans was noted (3.7 ± 2.8 %; p < 0.01), and appeared to be related to tumor growth as indicated by a significant correlation of TBR and tumor volume (r = 0.77; p < 0.0001). After correction for tumor growth TBR showed high longitudinal stability with an ICC of 0.84. Dex treatment induced a significant decrease of the TBR (-8.2 ± 6.1 %; p < 0.03), but did not influence the slope of the tumor TAC.
conclusionTBR of (18)F-FET uptake and tracer kinetics in brain tumors showed high longitudinal stability. Dex therapy may induce a minor decrease of the TBR; this needs further investigation.
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