Evidence map›Paper›PMID 26646725›Full record

ArticleEpigenetics2015

Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes.

Semira Gonseth, Ritu Roy, E Andres Houseman, Adam J de Smith, Mi Zhou, Seung-Tae Lee, Sébastien Nusslé, Amanda W Singer, Margaret R Wrensch, Catherine Metayer and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

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  19. A unique methylation pattern co-segregates with neural tube defect statuses in Han Chinese pedigrees.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Semira Gonsetha Department of Epidemiology and Biostatistics ; Laboratory for Molecular Epidemiology; University of California ; San Francisco , CA , USA.
Ritu Royb Computational Biology Core; HDF Comprehensive Cancer Center; University of California ; San Francisco , CA , USA.
E Andres Housemanc College of Public Health and Human Sciences; Oregon State University ; Corvallis , OR , USA.
Adam J de Smitha Department of Epidemiology and Biostatistics ; Laboratory for Molecular Epidemiology; University of California ; San Francisco , CA , USA.
Mi Zhoua Department of Epidemiology and Biostatistics ; Laboratory for Molecular Epidemiology; University of California ; San Francisco , CA , USA.
Seung-Tae Leed Department of Laboratory Medicine ; Yonsei University College of Medicine ; Seoul , Republic of Korea.
Sébastien Nusslée Department of Environmental Science ; Policy & Management; University of California ; Berkeley , CA , USA.
Amanda W Singerf School of Public Health; University of California ; Berkeley , CA , USA.
Margaret R Wrenschg Department of Neurological Surgery ; University of California ; San Francisco , CA , USA.
Catherine Metayerf School of Public Health; University of California ; Berkeley , CA , USA.
Joseph L Wiemelsa Department of Epidemiology and Biostatistics ; Laboratory for Molecular Epidemiology; University of California ; San Francisco , CA , USA.
University of California System · USUniversity of California, Berkeley · USUniversity of California, San Francisco · USCorvallis Environmental Center · USLaboratory of Molecular Genetics · PLUCSF Helen Diller Family Comprehensive Cancer Center · USYonsei University · KR

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
Genome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1M
Project 3 - Prenatal Exposures, Constitutive Genetics, DNA Methylation & Childhood LeukemiaP50ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2015 to 2019
$3.8M
Project 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7M
NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA155461NCI NIH HHS R01CA155461NIEHS NIH HHS P01 ES018172NIEHS NIH HHS P01ES018172NIEHS NIH HHS P50 ES018172NIEHS NIH HHS R01ES09137
6 · The paper itself

Abstract

Folate deficiency during early embryonic development constitutes a risk factor for neural tube defects and potentially for childhood leukemia via unknown mechanisms. We tested whether folate consumption during the 12 months prior to conception induced DNA methylation modifications at birth in healthy neonates with a genome-wide and agnostic approach. We hypothesized that DNA methylation in genes involved in neural tube development and/or cancer susceptibility would be affected by folate exposure. We retrospectively assessed folate exposure at the time of conception by food-frequency questionnaires administered to the mothers of 343 healthy newborns. We measured genome-wide DNA methylation from neonatal blood spots. We implemented a method based on bootstrap resampling to decrease false-positive findings. Folate was inversely associated with DNA methylation throughout the genome. Among the top folate-associated genes that were replicated in an independent Gambian study were TFAP2A, a gene critical for neural crest development, STX11, a gene implicated in acute myeloid leukemia, and CYS1, a candidate gene for cystic kidney disease. Reduced periconceptional folate intake was associated with increased methylation and, in turn, decreased gene expression at these 3 loci. The top folate-sensitive genes defined by their associated CpG sites were enriched for numerous transcription factors by Gene Set Enrichment Analysis, including those implicated in cancer development (e.g., MYC-associated zinc finger protein). The influence of estimated periconceptional folate intake on neonatal DNA methylation levels provides potential mechanistic insights into the role of this vitamin in the development of neural tube defects and childhood cancers.

Indexed as

DNA MethylationGene Expression Regulation, DevelopmentalGenes, NeoplasmDietary SupplementsEpigenomicsFemaleFertilizationFolic AcidFolic Acid DeficiencyHumansInfant, NewbornMembrane ProteinsNeural CrestNeural Tube DefectsPregnancyPrenatal Exposure Delayed EffectsCYS1 protein, humanFolic AcidMembrane ProteinsQa-SNARE ProteinsSTX11 protein, humanTFAP2A protein, humanTranscription Factor AP-2cancer preventiondevelopmental origin of health and diseaseDNA methylationepigeneticsfolateneural tube defects

Identifiers

PMID26646725
PMCPMC4844202
OpenAlexW2202286106

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.