Evidence map›Paper›PMID 26646678›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016

Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFNγ Autoantibodies.

Yingda L Xie, Lindsey B Rosen, Irini Sereti, Daniel L Barber, Ray Y Chen, Denise C Hsu, S Sonia Qasba, Christa S Zerbe, Steven M Holland, Sarah K Browne

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Utility ofOpen forum infectious diseases · 2024
    Article
  2. Article
  3. Article
  4. Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Diagnostic and Therapeutic Challenges in DisseminatedOpen forum infectious diseases · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Case Report: DisseminatedThe American journal of tropical medicine and hygiene · 2019
    Article
  14. Article
  15. Article
  16. Review
  17. Interferon-gamma response to the treatment of active pulmonary and extra-pulmonary tuberculosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017
    Observational
  18. Reply to Tham et al.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yingda L XieLaboratory of Clinical Infectious Diseases.
Lindsey B RosenLaboratory of Clinical Infectious Diseases.
Irini SeretiLaboratory of Immunoregulation.
Daniel L BarberLaboratory of Parasitic Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Heath, Bethesda.
Ray Y ChenLaboratory of Clinical Infectious Diseases.
Denise C HsuLaboratory of Immunoregulation.
S Sonia QasbaMontgomery County Health Department, Silver Spring, Maryland.
Christa S ZerbeLaboratory of Clinical Infectious Diseases.
Steven M HollandLaboratory of Clinical Infectious Diseases.
Sarah K BrowneLaboratory of Clinical Infectious Diseases.
Montgomery County Department of Health and Human Services · USNational Institute of Allergy and Infectious Diseases · US

Funding

Immunopathogenic Mechanisms of Human Immunodeficiency Virus (HIV) DiseaseZIAAI001121 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SERETI, IRINI · 2010 to 2025
$27.2M
Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Immune Regulation in Mycobacterial InfectionsZIAAI001171 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARBER, DANIEL · 2012 to 2025
$16.7M
GENES AND GENE PRODUCTS AS IMMUNOADJUVANTSZ01AI000647 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HOLLAND, STEVEN M · 1992 to 2008
$5.4M
International Research in ThailandZIAAI001069 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$4.3M
Rituximab for Anticytokine Autoantibody-Associated SyndromesZIAAI001182 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2013 to 2025
$3.0M
Intramural NIH HHS Z01 AI000647NIAID NIH HHS ZO1-AI00647-06
6 · The paper itself

Abstract

Interferon-gamma (IFNγ) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNγ-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNγ contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.

Indexed as

Anti-Bacterial AgentsAntibodies, NeutralizingAutoantibodiesFemaleHumansImmunoglobulin GInflammationInterferon-gammaMiddle AgedTuberculosis, MiliaryUnited StatesAnti-Bacterial AgentsAntibodies, NeutralizingAutoantibodiesImmunoglobulin GInterferon-gammaautoantibodiesdisseminated tuberculosisinterferon-gammaIRISparadoxical reaction

Identifiers

PMID26646678
PMCPMC4772847
OpenAlexW2289512335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.