ArticleMagma (New York, N.Y.)2016
DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model versus shutter-speed model--initial experience.
Article in Magma (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Prognostic impact of extracellular volume fraction derived from equilibrium contrast-enhanced CT in HCC patients receiving immune checkpoint inhibitors.Scientific reports · 2025Article
- Predictive value of dual-energy CT assessment of extracellular volume fraction on efficacy of immune checkpoint inhibitors in patients with liver cancer.Frontiers in oncology · 2025Article
- Current Imaging Diagnosis of Hepatocellular Carcinoma.Cancers · 2022Review
- Reproducibility of dynamic contrast enhanced MRI derived transfer coefficient Ktrans in lung cancer.PloS one · 2022Article
- Dynamic contrast-enhanced MRI perfusion quantification in hepatocellular carcinoma: comparison of gadoxetate disodium and gadobenate dimeglumine.European radiology · 2021Article
- Feasibility of perfusion and early-uptakeJapanese journal of radiology · 2021Article
- Applying arterial enhancement fraction (AEF) texture features to predict the tumor response in hepatocellular carcinoma (HCC) treated with Transarterial chemoembolization (TACE).Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Characterizing Errors in Pharmacokinetic Parameters from Analyzing Quantitative Abbreviated DCE-MRI Data in Breast Cancer.Tomography (Ann Arbor, Mich.) · 2021Article
- Correlation of radiomic features on dynamic contrast-enhanced magnetic resonance with microvessel density in hepatocellular carcinoma based on different models.The Journal of international medical research · 2021Article
- Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma.BioMed research international · 2020Article
- Reliability of dynamic contrast-enhanced magnetic resonance imaging data in primary brain tumours: a comparison of Tofts and shutter speed models.Neuroradiology · 2019Article
- Estimation of cellular-interstitial water exchange in dynamic contrast enhanced MRI using two flip angles.NMR in biomedicine · 2019Article
- Perfusion Magnetic Resonance as a Biomarker for Sorafenib-Treated Advanced Hepatocellular Carcinoma: A Pilot Study.GE Portuguese journal of gastroenterology · 2019Article
- Recent advances in non-invasive magnetic resonance imaging assessment of hepatocellular carcinoma.World journal of gastroenterology · 2018Review
- Dynamic Contrast-Enhanced MRI-Derived Intracellular Water Lifetime (τAJNR. American journal of neuroradiology · 2018Article
- Multiparametric FDG-PET/MRI of Hepatocellular Carcinoma: Initial Experience.Contrast media & molecular imaging · 2018Article
- Early perfusion changes within 1 week of systemic treatment measured by dynamic contrast-enhanced MRI may predict survival in patients with advanced hepatocellular carcinoma.European radiology · 2017Article
- Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging.Scientific reports · 2017Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo quantify hepatocellular carcinoma (HCC) perfusion and flow with the fast exchange regime-allowed Shutter-Speed model (SSM) compared to the Tofts model (TM). MATERIALS AND
methodsIn this prospective study, 25 patients with HCC underwent DCE-MRI. ROIs were placed in liver parenchyma, portal vein, aorta and HCC lesions. Signal intensities were analyzed employing dual-input TM and SSM models. ART (arterial fraction), K (trans) (contrast agent transfer rate constant from plasma to extravascular extracellular space), ve (extravascular extracellular volume fraction), kep (contrast agent intravasation rate constant), and τi (mean intracellular water molecule lifetime) were compared between liver parenchyma and HCC, and ART, K (trans), v e and k ep were compared between models using Wilcoxon tests and limits of agreement. Test-retest reproducibility was assessed in 10 patients.
resultsART and v e obtained with TM; ART, ve, ke and τi obtained with SSM were significantly different between liver parenchyma and HCC (p < 0.04). Parameters showed variable reproducibility (CV range 14.7-66.5% for both models). Liver K (trans) and ve; HCC ve and kep were significantly different when estimated with the two models (p < 0.03).
conclusionOur results show differences when computed between the TM and the SSM. However, these differences are smaller than parameter reproducibilities and may be of limited clinical significance.
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