Trial reportTrials2015
The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial.
Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01983800 (Use of Volatile Anesthetics for Long-Term Sedation In Critically Ill Patients), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Volatile Anesthetics for Long-Term Sedation In Critically Ill Patients
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Effect of Inhaled Volatile and IV Anesthetics on Biological Markers of Inflammation in Adult ICU and Thoracic Surgical Patients: A Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Volatile sedation in critically ill adults undergoing mechanical ventilation: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2025Pooled it
- Interventions for preventing intensive care unit delirium in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation (PROACTIVE): An Open-Label Randomized Controlled Trial.Critical care medicine · 2025Trial
- Article
- Early and late effects of volatile sedation with sevoflurane on respiratory mechanics of critically ill COPD patients.Annals of intensive care · 2024Article
- Article
- Article
- Adult sedation and analgesia in a resource limited intensive care unit - A Systematic Review and evidence based guideline.Annals of medicine and surgery (2012) · 2021Review
- Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia CaNeurochemical research · 2021Article
- Inased (inhaled sedation in ICU) trial protocol: a multicentre randomised open-label trial.BMJ open · 2021Article
- Prolonged anesthesia alters brain synaptic architecture.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Longitudinal impact on rat cardiac tissue transcriptomic profiles due to acute intratracheal inhalation exposures to isoflurane.PloS one · 2021Article
- Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients-A Case Series and Systematic Review.Critical care explorations · 2020Article
- The Use of Volatile Anesthetics as Sedatives for Acute Respiratory Distress Syndrome.Translational perioperative and pain medicine · 2019Article
- Uncontrolled delivery of liquid volatile anaesthetic when using the anaesthetic conserving device.Journal of clinical monitoring and computing · 2018Article
- Exertional rhabdomyolysis and heat stroke: Beware of volatile anesthetic sedation.World journal of critical care medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSedatives are administered to 85% of intensive care unit (ICU) patients. The most commonly used sedatives are intravenous benzodiazepines and propofol. These agents are associated with over-sedation in 40 to 60% of patients, which can lead to prolonged intubation, delirium and drug-induced hypotension. Evidence is increasing that volatile anesthetic agents are associated with faster extubation times, improved cardiovascular stability with no end-organ toxicity in comparison to our standard intravenous agents for short-term critical care sedation. Use of volatile agents within the ICU is a novel technique using a specialized delivery and scavenging system, which requires staff training and cultural acceptance. This pilot randomized controlled trial aims to assess the safety and feasibility of delivering volatile agents for long-term patient sedation in the ICU with limited or no experience of this technique. METHODS/
designThis is a prospective multicenter pragmatic pilot RCT that is blinded to the data analyst. This study aims to recruit 60 adult ICU patients requiring mechanical ventilation and sedation for more than 48 h. Patients will be randomized 2:1 to receive inhaled isoflurane (40 patients) or intravenous midazolam and/or propofol (20 patients) sedation. Sedation is titrated to a targeted Sedation Analgesia Score (SAS) using an explicit sedation-analgesia algorithm until extubation or tracheostomy. Primary safety and feasibility outcomes will assess atmospheric volatile concentration levels and adherence to our sedation-analgesia protocol. Secondary outcomes include time to extubation, duration of ventilation, quality of sedation, delirium, vasoactive drug support, length of stay, serum fluoride levels and mortality. DISCUSSION: This pilot project will serve as the basis for a larger RCT that will be powered for important clinical outcomes.
trial registrationClinicalTrials.gov, NCT01983800 (registration date 2 July 2013).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.