ArticleHepatology (Baltimore, Md.)2016
Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women.
Article in Hepatology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Seroprevalence of hepatitis E in general, hepatic, and pregnant populations in Nepal, Bangladesh, and Pakistan: a systematic review and meta-analysis.Virology journal · 2025Pooled it
- Hepatitis E infection among Ghanaians: a systematic review.Infectious diseases of poverty · 2017Pooled it
- Current global estimates, risk factors, and knowledge gaps for Hepatitis E virus (HEV): A scoping review.PLoS neglected tropical diseases · 2026Article
- Article
- Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review.Infection and drug resistance · 2024Review
- [Strengthening the study of chronic hepatitis E].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Hepatitis E in immunocompromised individuals.World journal of hepatology · 2022Review
- Hepatitis E Infection in a Longitudinal Cohort of Hepatitis C Virus and HCV/HIV Coinfected Persons.AIDS research and human retroviruses · 2021Article
- Swine hepatitis E virus: Cross-species infection, pork safety and chronic infection.Virus research · 2020Review
- Viral Hepatitis E and Chronicity: A Growing Public Health Concern.Frontiers in microbiology · 2020Review
- Seroprevalence of AIH-related autoantibodies in patients with acute hepatitis E viral infection: a prospective case-control study in China.Emerging microbes & infections · 2020Article
- The Clinical Perspective on Hepatitis E.Viruses · 2019Review
- Hepatitis E Infection in HIV-Infected Patients.Frontiers in microbiology · 2019Article
- Human immunodeficiency virus and liver disease: A comprehensive update.Hepatology communications · 2017Article
- Prevalence and risk of hepatitis E virus infection in the HIV population of Nepal.Virology journal · 2017Article
- Hepatitis E virus infections in travellers: assessing the threat to the Australian blood supply.Blood transfusion = Trasfusione del sangue · 2017Article
- Hepatitis E virus infection and hepatic GvHD in allogeneic hematopoietic stem cell transplantation recipients.Bone marrow transplantation · 2017Article
- Liver involvement in human immunodeficiency virus infection.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Review
- Sofosbuvir in the Treatment of Hepatitis E virus Infection: A Review ofJournal of clinical and experimental hepatologyReview
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
unlabelledExposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV/human immunodeficiency virus (HIV) coinfection in U.S. POPULATIONS: We tested 2,919 plasma samples collected from HIV-infected (HIV(+)) women and men enrolled in U.S. cohort studies for HEV viremia using a high-throughput nucleic acid testing (NAT) platform. NAT(+) samples were confirmed by real-time polymerase chain reaction. Samples were selected for testing primarily on the basis of biomarkers of liver disease and immune suppression. Prevalence of HEV viremia was 3 of 2,606 and 0 of 313 in tested plasma samples collected from HIV(+) women and men, respectively. All HEV isolates were genotype 3a. Based on follow-up testing of stored samples, 1 woman had chronic HEV infection for >4 years whereas 2 women had acute HEV detectable at only a single study visit.
conclusionsTo our knowledge, this is the first reported case of chronic HEV infection in an HIV(+) U.S. individual. We also confirm that chronic HEV infection can persist despite a CD4(+) count >200 cells/mm(3). Overall, though, these data suggest that HEV infection is rare in the HIV(+) U.S. population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.