Evidence map›Paper›PMID 26646118›Full record

ReviewNeurocritical care2016

Prophylaxis of Venous Thrombosis in Neurocritical Care Patients: An Evidence-Based Guideline: A Statement for Healthcare Professionals from the Neurocritical Care Society.

Paul Nyquist, Cynthia Bautista, Draga Jichici, Joseph Burns, Sanjeev Chhangani, Michele DeFilippis, Fernando D Goldenberg, Keri Kim, Xi Liu-DeRyke, William Mack and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 5 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 5 syntheses or guidelines pooled it, 178 citations in OpenAlex.

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  7. The dilemma of thromboprophylaxis in stroke patients.Clinical medicine (London, England) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 11 institutions in 2 countries.

Paul NyquistDepartments of Neurology, Anesthesia/Critical Care Medicine, Neurosurgery, and General Internal Medicine, John Hopkins School of Medicine, 733 N Broadway, Baltimore, MD, 21205, USA. pnyquis1@jhmi.edu.
Cynthia BautistaDepartment of Nursing, Neuroscience CNS, Yale-New Haven Hospital, New Haven, CT, 06510, USA. cynthia.bautista@ynhh.org.
Draga JichiciDepartment of Neurology and Critical Care, McMaster University, 1280 Main Street W, Hamilton, ON, L8S 4L8, Canada. draga.jichici@mcmaster.ca.
Joseph BurnsDepartment of Neurology, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA, 01805, USA. joseph.burns@lahey.org.
Sanjeev ChhanganiDepartment of Anesthesia, Critical Care and Pain Medicine, 55 Fruit Street, Boston, MA, 02114-2696, USA. schhangani@mgh.harvard.edu.
Michele DeFilippisDepartment of Nursing, Morristown Medical Center, 100 Madison Ave, Morristown, NJ, 07960, USA. michele.defilippis@atlantichealth.org.
Fernando D GoldenbergDepartment of Neurology, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL, 60637, USA. fgoldenb@neurology.bsd.uchicago.edu.
Keri KimDepartment of Neurosurgery, University of Illinois Hospital & Health Sciences System, 833 South Wood Street, RM164 MC886, Chicago, IL, 60612, USA. skim42@uic.edu.
Xi Liu-DeRykeDivision of Surgical Critical Care, Orlando Regional Medical Center, 1414 Kuhl Ave, MP180, Orlando, FL, 32806, USA. xiliu713@icloud.com.
William MackDepartment of Neurosurgery, Los Angeles County University Southern California Medical Center, 1520 San Pablo St, Los Angeles, CA, 90033, USA. wjmack@gmial.com.
Kim MeyerDepartment of Neurosurgery, University of Louisville Physicians, 401 E Chestnut St, Louisville, KY, 40202, USA. ksmeyer21@gmail.com.
Center for Pain and the Brain · USJohns Hopkins Medicine · USLahey Hospital and Medical Center · USLos Angeles Medical Center · USMcMaster University · CAMorristown Medical Center · USOrlando Regional Medical Center · USUniversity of Chicago · USUniversity of Illinois Chicago · USUniversity of Louisville Physicians · USYale New Haven Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of death from venous thromboembolism (VTE) is high in intensive care unit patients with neurological diagnoses. This is due to an increased risk of venous stasis secondary to paralysis as well as an increased prevalence of underlying pathologies that cause endothelial activation and create an increased risk of embolus formation. In many of these diseases, there is an associated risk from bleeding because of standard VTE prophylaxis. There is a paucity of prospective studies examining different VTE prophylaxis strategies in the neurologically ill. The lack of a solid evidentiary base has posed challenges for the establishment of consistent and evidence-based clinical practice standards. In response to this need for guidance, the Neurocritical Care Society set out to develop and evidence-based guideline using GRADE to safely reduce VTE and its associated complications.

Indexed as

Critical CareEvidence-Based MedicineHumansNeurologyPractice Guidelines as TopicSocieties, MedicalVenous ThromboembolismIntracranial hemorrhagePulmonary embolusStrokeSubarachnoid hemorrhageTraumatic brain injuryVenous thrombus

Identifiers

PMID26646118
OpenAlexW2190676781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.