ReviewThe journal of sexual medicine2015
Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction.
Review in The journal of sexual medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between Prediabetes and Erectile Dysfunction: A Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- A systematic review of the long-term efficacy of low-intensity shockwave therapy for vasculogenic erectile dysfunction.International urology and nephrology · 2019Pooled it
- Low-intensity shockwave therapy (LiST) for erectile dysfunction: a randomized clinical trial assessing the impact of energy flux density (EFD) and frequency of sessions.International journal of impotence research · 2020Trial
- The relationship between atherogenic index of plasma and erectile dysfunction: a cross-sectional observational study.World journal of urology · 2026Observational
- Sexual dysfunction in chronic hepatitis B: a comprehensive review of pathophysiology, clinical burden, and integrated management.Frontiers in public health · 2026Review
- Association of total testosterone levels with cardiometabolic diseases in men with erectile dysfunction.Sexual medicine · 2024Article
- Uncovering the Penile Clock: Expression of Molecular Clock Proteins in Human Penile Cavernous Tissue.The world journal of men's health · 2024Article
- Cardiometabolic Disorder and Erectile Dysfunction.Cell biochemistry and biophysics · 2024Review
- Vasorelaxant and hypotensive effects of an ethanolic extract ofFrontiers in pharmacology · 2024Article
- Sexual dysfunction is highly prevalent in male survivors of malignant lymphoma.Sexual medicine · 2023Article
- Tofacitinib monotherapy and erectile dysfunction in rheumatoid arthritis: a pilot observational study.Rheumatology international · 2022Observational
- Potential Effect of the Circadian Clock on Erectile Dysfunction.Aging and disease · 2022Article
- Assessment of a New Formulation of Sildenafil on Common Practice: An Observational Study.International journal of reproductive medicine · 2022Article
- Single-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction.Frontiers in endocrinology · 2022Article
- Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- The Combination of High-Fat Diet and Oral Marijuana Promotes the Development of Fibrosis in the Mouse Corpora Cavernosa.Sexual medicine · 2021Article
- The emerging role of aldosterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction.Endocrine · 2018Review
- Effects of Vitamin D Restricted Diet Administered during Perinatal and Postnatal Periods on the Penis of Wistar Rats.BioMed research international · 2018Article
- A novel experimental model of erectile dysfunction in rats with heart failure using volume overload.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
introductionAlthough clinical evidence supports an association between cardiovascular/metabolic diseases (CVMD) and erectile dysfunction (ED), scientific evidence for this link is incompletely elucidated.
aimThis study aims to provide scientific evidence for the link between CVMD and ED.
methodsIn this White Paper, the Basic Science Committee of the Sexual Medicine Society of North America assessed the current literature on basic scientific support for a mechanistic link between ED and CVMD, and deficiencies in this regard with a critical assessment of current preclinical models of disease.
resultsA link exists between ED and CVMD on several grounds: the endothelium (endothelium-derived nitric oxide and oxidative stress imbalance); smooth muscle (SM) (SM abundance and altered molecular regulation of SM contractility); autonomic innervation (autonomic neuropathy and decreased neuronal-derived nitric oxide); hormones (impaired testosterone release and actions); and metabolics (hyperlipidemia, advanced glycation end product formation).
conclusionBasic science evidence supports the link between ED and CVMD. The Committee also highlighted gaps in knowledge and provided recommendations for guiding further scientific study defining this risk relationship. This endeavor serves to develop novel strategic directions for therapeutic interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.