Evidence map›Paper›PMID 26645998›Full record

SynthesisNeurochemical research2016

Neuroprotective Effect of Natural Products on Peripheral Nerve Degeneration: A Systematic Review.

Heitor G Araújo-Filho, Lucindo J Quintans-Júnior, André S Barreto, Jackson R G S Almeida, Rosana S S Barreto, Jullyana S S Quintans

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Effects of Resistance Training andAntioxidants (Basel, Switzerland) · 2020
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Heitor G Araújo-FilhoDepartment of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, São Cristóvão, SE, CEP: 49.000-100, Brazil.
Lucindo J Quintans-JúniorDepartment of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, São Cristóvão, SE, CEP: 49.000-100, Brazil.
André S BarretoDepartment of Health Education, Federal University of Sergipe, São Cristóvão, SE, Brazil.
Jackson R G S AlmeidaDepartment of Pharmaceutical Science, Federal University of Vale do São Francisco, Petrolina, PE, Brazil.
Rosana S S BarretoDepartment of Health Education, Federal University of Sergipe, São Cristóvão, SE, Brazil.
Jullyana S S QuintansDepartment of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, São Cristóvão, SE, CEP: 49.000-100, Brazil. jullyanaquintans@gmail.com.ORCID http://orcid.org/0000-0001-6507-8982
Universidade Federal de Sergipe · BRUniversidade Federal do Vale do São Francisco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injury (PNI) is a serious public health problem that is linked with motor, sensory and autonomic deficits. Given the fact that this type of disorder leads to a decreased quality of life in most patients and adherence of available drugs is limited and have adverse effects, we investigated the efficacy of natural products in a PNI model. The search terms plants, medicinal, nerve regeneration, nerve crush, sciatic nerve as well as MeSH terms or free-text words were used to retrieve English language articles in PubMed, Scopus, Web of Science and LILACS published until July 2015. After sciatic nerve crush, natural products have improved significantly motor performance, sensory function and electrical conductance measured over weeks. Among the pharmacological targets suggested by the action of natural products, there were citations on the activation of the antiapoptotic signaling pathway, modulation in the expression of pro-inflammatory cytokines and neurotrophic factors. The systematic review provides scientific evidence that natural products are pharmacologically effective in the treatment of PNI such as sciatic nerve crush.

Indexed as

AnimalsBiological ProductsHumansNerve RegenerationNeurodegenerative DiseasesPeripheral Nerve InjuriesPeripheral Nervous System DiseasesPlant ExtractsBiological ProductsPlant ExtractsMedicinal plantNatural productsNerve regenerationPeripheral nerve injurySciatic nerve crush

Identifiers

PMID26645998
OpenAlexW2192655551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.