SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2016
The prognostic role of abnormal liver function in IVIG unresponsiveness in Kawasaki disease: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Beyond biochemical recovery: rethinking liver dysfunction in Kawasaki disease.Translational pediatrics · 2026Article
- A nomogram for predicting Kawasaki Disease in acutely febrile children with liver injury.European journal of pediatrics · 2026Article
- Decoding clinical heterogeneity and age-related coronary risk in incomplete Kawasaki disease: a multicenter cluster analysis and structural equation modeling study.Frontiers in immunology · 2026Article
- Cholestasis as a complication in Kawasaki disease: an atypical clinical presentation.European journal of medical research · 2025Article
- Analysis of the clinical characteristics of patients with Kawasaki disease complicated with cholestasis.BMC pediatrics · 2024Article
- Unraveling the gut: the pivotal role of intestinal mechanisms in Kawasaki disease pathogenesis.Frontiers in immunology · 2024Review
- Subgroups of children with Kawasaki disease: a data-driven cluster analysis.The Lancet. Child & adolescent health · 2023Article
- Clinical features analysis of Kawasaki disease with abdominal symptoms as the first manifestation.European journal of pediatrics · 2023Article
- Jaundice-predominant manifestation of Kawasaki disease in children.Frontiers in pediatrics · 2023Article
- Kawasaki Disease with Hepatobiliary Manifestations.Medicina (Kaunas, Lithuania) · 2022Article
- Serum alanine aminotransferase level and intravenous immunoglobulin resistance in patients with kawasaki disease.Clinical rheumatology · 2022Article
- Clinical indications for Kawasaki disease in febrile infants aged less than three months.Rheumatology international · 2022Article
- Predicting Intravenous Immunoglobulin Resistance Among North American Children Hospitalized With Kawasaki Disease.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Kawasaki disease in Malaysia: Biochemical profile, characterization, diagnosis and treatment.Frontiers in pediatrics · 2022Article
- Prediction of repeated intravenous immunoglobulin resistance in children with Kawasaki disease.BMC pediatrics · 2021Article
- Atypically Protracted Course of Liver Involvement in Kawasaki Disease. Case Report and Literature Review.Pediatric reports · 2021Article
- A novel score system of blood tests for differentiating Kawasaki disease from febrile children.PloS one · 2021Article
- Factors Predicting Resistance to Intravenous Immunoglobulin and Coronary Complications in Kawasaki Disease: IVIG Resistance in Kawasaki Disease.Korean circulation journal · 2018Article
- Typical Kawasaki Disease Presenting With Pancreatitis and Bilateral Parotid Gland Involvement: A Case Report and Literature Review.Frontiers in pediatrics · 2018Article
- [Clinical features of children with incomplete Kawasaki disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to assess the prognostic role of liver function alteration with intravenous immunoglobulin (IVIG) resistance in patients with Kawasaki disease (KD) by systematically analyzing and summarizing the results from published studies.
methodsIn this study, we summarized the evidence currently available up to March 31, 2015, and calculated the standard mean difference (SMD) of liver function parameters, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and total bilirubin between IVIG-responsive and IVIG-resistant patients.
resultsWe found that the serum levels of these parameters in IVIG-non-responsive patients were significantly higher than that in IVIG-responsive group (total bilirubin: SMD = 0.984, 95%CI 0.712-1.184, p < 0.005; ALT: SMD = 0.555, 95%CI 0.400-0.710, p < 0.005; AST: SMD = 0.602, 95%CI 0.413-0.791, p < 0.005; GGT = 0.551, 95%CI 0.157-0.946, p = 0.006). There was evidence of heterogeneity (I (2) > 50%). The characteristics of patients could be the major sources, as analysis stratified by region significantly removed or reduced the heterogeneity.
conclusionIn summary, our meta-analysis suggested that liver abnormality was significantly associated with IVIG unresponsiveness in KD patients. Further study from more clinical investigations is needed to confirm this finding.
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