ReviewUrolithiasis2016
Oxalate-degrading microorganisms or oxalate-degrading enzymes: which is the future therapy for enzymatic dissolution of calcium-oxalate uroliths in recurrent stone disease?
Review in Urolithiasis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Gut microbiota in patients with kidney stones: a systematic review and meta-analysis.BMC microbiology · 2023Pooled it
- Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis.Urolithiasis · 2020Pooled it
- AI-driven credibility profiling of real-world patient experiences suggests overlooked kidney stone therapies warrant further investigation.Research square · 2026Article
- Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet.Gut microbes · 2025Article
- Accumulation of heavy metals in the mycelium of Abortiporus biennis and their effect on oxalate oxidase activity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Role of oxalic acid in fungal and bacterial metabolism and its biotechnological potential.World journal of microbiology & biotechnology · 2024Review
- Navigating the Evolving Landscape of Primary Hyperoxaluria: Traditional Management Defied by the Rise of Novel Molecular Drugs.Biomolecules · 2024Review
- The intestinal microbiome of children with initial and recurrent nephrolithiasis: A pilot study and exploratory analysis.Journal of pediatric urology · 2024Article
- Cloning and Molecular Characterization ofJournal of fungi (Basel, Switzerland) · 2022Article
- Perspectives in primary hyperoxaluria - historical, current and future clinical interventions.Nature reviews. Urology · 2022Review
- Intestinal microbiota and kidney diseases.Kidney research and clinical practice · 2021Article
- Recent advances on the mechanisms of kidney stone formation (Review).International journal of molecular medicine · 2021Review
- Increased expression of LCN2 formed a positive feedback loop with activation of the ERK pathway in human kidney cells during kidney stone formation.Scientific reports · 2020Article
- Nephroprotective Effect ofBiomolecules · 2020Article
- The relationship between calcium oxalate lithiasis and chronic proinflammatory intestinal dysbiosis pattern: a prospective study.Urolithiasis · 2020Article
- Future treatments for hyperoxaluria.Current opinion in urology · 2020Review
- miR-125a-5p: a novel regulator of SLC26A6 expression in intestinal epithelial cells.American journal of physiology. Cell physiology · 2019Article
- Molecular basis of primary hyperoxaluria: clues to innovative treatments.Urolithiasis · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal urolithiasis is a pathological condition common to a multitude of genetic, physiological and nutritional disorders, ranging from general hyperoxaluria to obesity. The concept of quickly dissolving renal uroliths via chemolysis, especially calcium-oxalate kidney stones, has long been a clinical goal, but yet to be achieved. Over the past 25 years, there has been a serious effort to examine the prospects of using plant and microbial oxalate-degrading enzymes known to catabolize oxalic acid and oxalate salts. While evidence is emerging that bacterial probiotics can reduce recurrent calcium-oxalate kidney stone disease by lowering systemic hyperoxaluria, the possible use of free oxalate-degrading enzyme therapy remains a challenge with several hurdles to overcome before reaching clinical practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.