Evidence map›Paper›PMID 26645862›Full record

Observational studyEuropean radiology2016

Solid pulmonary nodule risk assessment and decision analysis: comparison of four prediction models in 285 cases.

Simone Perandini, Gian Alberto Soardi, Massimiliano Motton, Arianna Rossi, Manuel Signorini, Stefania Montemezzi

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. [Prognosis factors analysis of patients with malignant solitary pulmonary nodules].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020
    Article
  10. Article
  11. Editorial commentary: meeting a paramount challenge.Translational lung cancer research · 2018
    Article
  12. Article
  13. Observational
  14. LUNGx Challenge for computerized lung nodule classification.Journal of medical imaging (Bellingham, Wash.) · 2016
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simone PerandiniDepartment of Radiology, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, Verona, Italy, 37124. mail@simoneperandini.com.
Gian Alberto SoardiDepartment of Radiology, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, Verona, Italy, 37124.
Massimiliano MottonDepartment of Radiology, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, Verona, Italy, 37124.
Arianna RossiDepartment of Radiology, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, Verona, Italy, 37124.
Manuel SignoriniDepartment of Radiology, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, Verona, Italy, 37124.
Stefania MontemezziDepartment of Radiology, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Stefani 1, Verona, Italy, 37124.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to compare classification results from four major risk prediction models in a wide population of incidentally detected solitary pulmonary nodules (SPNs) which were selected to crossmatch inclusion criteria for the selected models.

methodsA total of 285 solitary pulmonary nodules with a definitive diagnosis were evaluated by means of four major risk assessment models developed from non-screening populations, namely the Mayo, Gurney, PKUPH and BIMC models. Accuracy was evaluated by receiver operating characteristic (ROC) area under the curve (AUC) analysis. Each model's fitness to provide reliable help in decision analysis was primarily assessed by adopting a surgical threshold of 65 % and an observation threshold of 5 % as suggested by ACCP guidelines.

resultsROC AUC values, false positives, false negatives and indeterminate nodules were respectively 0.775, 3, 8, 227 (Mayo); 0.794, 41, 6, 125 (Gurney); 0.889, 42, 0, 144 (PKUPH); 0.898, 16, 0, 118 (BIMC).

conclusionsResultant data suggests that the BIMC model may be of greater help than Mayo, Gurney and PKUPH models in preoperative SPN characterization when using ACCP risk thresholds because of overall better accuracy and smaller numbers of indeterminate nodules and false positive results. KEY POINTS: • The BIMC and PKUPH models offer better characterization than older prediction models • Both the PKUPH and BIMC models completely avoided false negative results • The Mayo model suffers from a large number of indeterminate results.

Indexed as

Area Under CurveDecision Support TechniquesFemaleHumansLung NeoplasmsMaleMiddle AgedModels, TheoreticalRisk AssessmentROC CurveSolitary Pulmonary NoduleTomography, X-Ray ComputedComputer aided diagnosisCTDecision analysisLung cancerSolitary pulmonary nodule

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.