Evidence map›Paper›PMID 26645834›Full record

ArticleJournal of the American Heart Association2015

Short-Term Exposure to Fine Particulate Matter Air Pollution Is Preferentially Associated With the Risk of ST-Segment Elevation Acute Coronary Events.

C Arden Pope, Joseph B Muhlestein, Jeffrey L Anderson, John B Cannon, Nicholas M Hales, Kent G Meredith, Viet Le, Benjamin D Horne

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 139 citations in OpenAlex.

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  13. Air pollution and myocardial infarction in Poland.The Lancet regional health. Europe · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

C Arden PopeDepartment of Economics, Brigham Young University, Provo, UT (A.P., J.B.C., N.M.H.).
Joseph B MuhlesteinIntermountain Heart Institute, Intermountain Medical Center, Murray, UT (J.B.M., J.L.A., K.G.M., V.L., B.D.H.) Department of Internal Medicine, University of Utah, Salt Lake City, UT (J.B.M., J.L.A., B.D.H.).
Jeffrey L AndersonIntermountain Heart Institute, Intermountain Medical Center, Murray, UT (J.B.M., J.L.A., K.G.M., V.L., B.D.H.) Department of Internal Medicine, University of Utah, Salt Lake City, UT (J.B.M., J.L.A., B.D.H.).
John B CannonDepartment of Economics, Brigham Young University, Provo, UT (A.P., J.B.C., N.M.H.).
Nicholas M HalesDepartment of Economics, Brigham Young University, Provo, UT (A.P., J.B.C., N.M.H.).
Kent G MeredithIntermountain Heart Institute, Intermountain Medical Center, Murray, UT (J.B.M., J.L.A., K.G.M., V.L., B.D.H.).
Viet LeIntermountain Heart Institute, Intermountain Medical Center, Murray, UT (J.B.M., J.L.A., K.G.M., V.L., B.D.H.).
Benjamin D HorneIntermountain Heart Institute, Intermountain Medical Center, Murray, UT (J.B.M., J.L.A., K.G.M., V.L., B.D.H.) Department of Internal Medicine, University of Utah, Salt Lake City, UT (J.B.M., J.L.A., B.D.H.).
Intermountain Medical Center · USBrigham Young University · USUniversity of Utah · US

Funding

Endothelial Progenitor Cells and Particulate Air PollutionR01ES019217 · NIEHS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI, O'TOOLE, TIMOTHY E · 2011 to 2022
$6.0M
NIEHS NIH HHS ES019217NIEHS NIH HHS R01 ES019217
6 · The paper itself

Abstract

backgroundAir pollution is associated with greater cardiovascular event risk, but the types of events and specific persons at risk remain unknown. This analysis evaluates effects of short-term exposure to fine particulate matter air pollution with risk of acute coronary syndrome events, including ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, unstable angina, and non-ST-segment elevation acute coronary syndrome. METHODS AND

resultsAcute coronary syndrome events treated at Intermountain Healthcare hospitals in urban areas of Utah's Wasatch Front were collected between September 1993 and May 2014 (N=16 314). A time-stratified case-crossover design was performed matching fine particulate matter air pollution exposure at the time of each event with referent periods when the event did not occur. Patients served as their own controls, and odds ratios were estimated using nonthreshold and threshold conditional logistic regression models. In patients with angiographic coronary artery disease, odds ratios for a 10-μg/m(3) increase in concurrent-day fine particulate matter air pollution >25 μg/m³ were 1.06 (95% CI 1.02-1.11) for all acute coronary syndrome, 1.15 (95% CI 1.03-1.29) for ST-segment elevation myocardial infarction, 1.02 (95% CI 0.97-1.08) for non-ST-segment elevation myocardial infarction, 1.09 (95% CI 1.02-1.17) for unstable angina, and 1.05 (95% CI 1.00-1.10) for non-ST-segment elevation acute coronary syndrome events. Excess risk from fine particulate matter air pollution exposure was not observed in patients without angiographic coronary artery disease.

conclusionsElevated fine particulate matter air pollution exposures contribute to triggering acute coronary events, especially ST-segment elevation myocardial infarction, in those with existing seriously diseased coronary arteries but not in those with nondiseased coronary arteries.

Indexed as

Acute Coronary SyndromeAngina, UnstableCase-Control StudiesCross-Over StudiesFemaleHumansInhalation ExposureMaleMiddle AgedMyocardial InfarctionParticulate MatterRisk FactorsUtahWeatherParticulate Matteracute coronary syndromeair pollutioncardiovascular diseaseparticulate matterST‐segment elevation myocardial infarction

Identifiers

PMID26645834
PMCPMC4845284
OpenAlexW2261720243

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.