Evidence map›Paper›PMID 26645547›Full record

ArticlePain2016

Vagus nerve stimulation inhibits cortical spreading depression.

Shih-Pin Chen, Ilknur Ay, Andreia Lopes de Morais, Tao Qin, Yi Zheng, Homa Sadeghian, Fumiaki Oka, Bruce Simon, Katharina Eikermann-Haerter, Cenk Ayata

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 69 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 4 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04126408 nacompletednot on this mapstarted 2020, after this paper: background citation

Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage

TypeinterventionalSponsorNorthwell HealthRan2020 to 2022Enrolled40ConditionsSubarachnoid Hemorrhage, AneurysmalArmsgammaCore
NCT05103566 narecruitingnot on this mapstarted 2022, after this paper: background citation

STORM: Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage

TypeinterventionalSponsorMassachusetts General HospitalRan2022 to 2029Enrolled25ConditionsSubarachnoid Hemorrhage, AneurysmalArmsgammaCore
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
  2. Non-invasive neuromodulation in the acute treatment of migraine: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  3. Systematic review of the pharmacological agents that have been tested against spreading depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Pooled it
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  9. Timing Considerations for Noninvasive Vagal Nerve Stimulation in Clinical Studies.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Shih-Pin ChenNeurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan Department of Neurology, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA ElectroCore LLC, Basking Ridge, NJ, USA Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Ilknur Ay
Andreia Lopes de Morais
Tao Qin
Yi Zheng
Homa Sadeghian
Fumiaki Oka
Bruce Simon
Katharina Eikermann-Haerter
Cenk Ayata
Apple (Israel) · IL

Funding

Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine ModelsR01NS061505 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK · 2008 to 2012
$1.8M
NINDS NIH HHS R01 NS061505
6 · The paper itself

Abstract

Vagus nerve stimulation has recently been reported to improve symptoms of migraine. Cortical spreading depression is the electrophysiological event underlying migraine aura and is a trigger for headache. We tested whether vagus nerve stimulation inhibits cortical spreading depression to explain its antimigraine effect. Unilateral vagus nerve stimulation was delivered either noninvasively through the skin or directly by electrodes placed around the nerve. Systemic physiology was monitored throughout the study. Both noninvasive transcutaneous and invasive direct vagus nerve stimulations significantly suppressed spreading depression susceptibility in the occipital cortex in rats. The electrical stimulation threshold to evoke a spreading depression was elevated by more than 2-fold, the frequency of spreading depressions during continuous topical 1 M KCl was reduced by ∼40%, and propagation speed of spreading depression was reduced by ∼15%. This effect developed within 30 minutes after vagus nerve stimulation and persisted for more than 3 hours. Noninvasive transcutaneous vagus nerve stimulation was as efficacious as direct invasive vagus nerve stimulation, and the efficacy did not differ between the ipsilateral and contralateral hemispheres. Our findings provide a potential mechanism by which vagus nerve stimulation may be efficacious in migraine and suggest that susceptibility to spreading depression is a suitable platform to optimize its efficacy.

Indexed as

Vagus Nerve StimulationAnimalsBrainCortical Spreading DepressionElectric StimulationMaleMigraine DisordersModels, AnimalRats, Sprague-Dawley

Identifiers

PMID26645547
PMCPMC4943574
OpenAlexW2319000318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.