Evidence map›Paper›PMID 26645510›Full record

ArticleSchizophrenia research2016

Unitary construct of generalized cognitive ability underlying BACS performance across psychotic disorders and in their first-degree relatives.

W C Hochberger, S K Hill, C L M Nelson, J L Reilly, R S E Keefe, G D Pearlson, M S Keshavan, C A Tamminga, B A Clementz, J A Sweeney

Abstract readValidation Study
In one paragraph

Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
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  16. Emotional intelligence in bipolar-I-disorder: A comparison between patients, unaffected siblings, and control subjects.European psychiatry : the journal of the Association of European Psychiatrists · 2020
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  19. Decomposing the constituent oscillatory dynamics underlying mismatch negativity generation in schizophrenia: Distinct relationships to clinical and cognitive functioning.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019
    Article
  20. Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

W C HochbergerRosalind Franklin University of Medicine and Science, Department of Psychology, United States.
S K HillRosalind Franklin University of Medicine and Science, Department of Psychology, United States. Electronic address: scot.hill@rosalindfranklin.edu.
C L M NelsonRosalind Franklin University of Medicine and Science, Department of Psychology, United States.
J L ReillyNorthwestern University, Department of Psychiatry and Behavioral Sciences, United States.
R S E KeefeDuke University, Departments of Psychiatry, Neuroscience, and Psychology, United States.
G D PearlsonYale University School of Medicine, Departments of Psychiatry & Neurobiology, United States.
M S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
C A TammingaUT Southwestern Medical Center at Dallas, Department of Psychiatry, United States.
B A ClementzUniversity of Georgia, Department of Psychology, United States.
J A SweeneyUT Southwestern Medical Center at Dallas, Department of Psychiatry, United States.

Funding

Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077852 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI THAKER, GUNVANT K · 2007 to 2010
$3.5M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077862 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SWEENEY, JOHN A · 2007 to 2010
$3.1M
Schizophrenia Pharmacogenetics: cognition and symptom response to antipsychoticsK08MH083888 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BISHOP, JEFFREY R · 2009 to 2013
$899k
Enhancing Cognition in SchizophreniaK23MH072767 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HILL, SCOT KRISTIAN · 2006 to 2010
$794k
NIMH NIH HHS K23 MH072767NIMH NIH HHS MH072767NIMH NIH HHS MH077851NIMH NIH HHS MH077852NIMH NIH HHS MH077862NIMH NIH HHS MH077945NIMH NIH HHS MH078113NIMH NIH HHS MH083888
6 · The paper itself

Abstract

Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognition in Schizophrenia (BACS) neuropsychological battery. Analyses were conducted on 783 psychosis spectrum probands (schizophrenia, schizoaffective, psychotic bipolar), 887 of their first-degree relatives, and 396 non-psychiatric controls from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Exploratory factor analysis of BACS subtest scores indicated a single-factor solution that was similar across all groups and provided the best overall data fit in confirmatory analyses. Correlations between the standard BACS composite score and the sum of subscale scores weighted by their loadings on this unitary factor were very high in all groups (r≥.99). Thus, the BACS assesses a similar unitary cognitive construct in probands with different psychotic disorders, in their first-degree relatives, and in healthy controls, and this factor is well measured by the test's standard composite score.

Indexed as

CognitionFamilyModels, PsychologicalSchizophrenic PsychologyAdultBipolar DisorderFactor Analysis, StatisticalFemaleGenetic Predisposition to DiseaseHumansMaleNeuropsychological TestsPsychotic DisordersSchizophreniaBrief Assessment of Cognition in SchizophreniaFactor analysisFirst-degree relativesPsychosis

Identifiers

PMID26645510
PMCPMC5226655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.