SynthesisEpidemiology and infection2016
The global burden of major infectious complications following prostate biopsy.
Synthesis in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Transrectal vs transperineal prostate biopsy: a systematic review and meta-analysis.BJU international · 2026Pooled it
- Transperineal biopsy devices in people with suspected prostate cancer - a systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2024Pooled it
- Infection risk reduction with povidone-iodine rectal disinfection prior to transrectal prostate biopsy: an updated systematic review and meta-analysis.World journal of urology · 2024Pooled it
- [Prostate biopsy-infection prophylaxis and patient preparation].Urologie (Heidelberg, Germany) · 2023Pooled it
- [Infectious complications following prostate biopsy-Major changes 2020].Der Urologe. Ausg. A · 2020Pooled it
- The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis.World journal of urology · 2018Pooled it
- Rectal Culture-Based Versus Empirical Antibiotic Prophylaxis to Prevent Infectious Complications in Men Undergoing Transrectal Prostate Biopsy: A Randomized, Nonblinded Multicenter Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- Effect of targeted prophylaxis with rectal swab on complications after prostate biopsy: prospective randomized study.Irish journal of medical science · 2022Trial
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- Infection rates of trans-perineal versus trans-rectal prostate biopsy: A Middle Eastern tertiary center experience-Time for a change?Arab journal of urology · 2026Article
- Identification of prostate cancer by urinary DLX1/HOXC6 expression in Chinese population with prostate-specific antigen levels of 4-10 ng/mL.Scientific reports · 2025Article
- Investigating infectious complications from transrectalTranslational andrology and urology · 2025Article
- Antibiotic prophylaxis for transperineal prostate biopsy.The Cochrane database of systematic reviews · 2025Article
- Rectal Swab-based Targeted Prophylactic Antibiotics Reduce Infectious Complications After Transrectal Prostate Biopsy: A Systematic Review and Meta-analysis of Randomized Controlled Trials.European urology open science · 2025Review
- Patient satisfaction rates and tolerance of free-hand ultrasound-guided transperineal prostate biopsy in an outpatient setting.Abdominal radiology (New York) · 2025Article
- Identifying the best candidate for focal therapy: a comprehensive review.Prostate cancer and prostatic diseases · 2025Review
- Clinical feasibility of MRI-guided in-bore prostate biopsies at 0.55T.Abdominal radiology (New York) · 2025Article
- The carbon footprint of transperineal prostate biopsy.BJUI compass · 2025Article
- Transperineal prostate biopsy under local vs general anaesthesia: a cost-effectiveness analysis.BJU international · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a systematic review providing estimates of the overall and regional burden of infectious complications following prostate biopsy. A directly standardized prevalence estimate was used because it reflects the burden of disease more explicitly. Complications included sepsis, hospitalization, bacteraemia, bacteriuria, and acute urinary retention after biopsy. There were 165 articles, comprising 162 577 patients, included in the final analysis. Our findings demonstrate that transrectal biopsy was associated with a higher burden of hospitalization (1·1% vs. 0·9%) and sepsis (0·8% vs. 0·1%) compared to transperineal biopsy, while acute urinary retention was more prevalent after transperineal than transrectal biopsy (4·2% vs. 0·9%). The differences were statistically non-significant because of large heterogeneity across countries. We also demonstrate and discuss regional variations in complication rates, with Asian studies reporting higher rates of sepsis and hospitalization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.