Evidence map›Paper›PMID 26645391›Full record

Trial reportJournal of neurology2016

Brief intervention by general practitioners for medication-overuse headache, follow-up after 6 months: a pragmatic cluster-randomised controlled trial.

Espen Saxhaug Kristoffersen, Jørund Straand, Kjersti Grøtta Vetvik, Jūratė Šaltytė Benth, Michael Bjørn Russell, Christofer Lundqvist

2 registry-linked trialsAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01314768 nacompletednot on this map

RCT of Structured Brief Intervention for Medication Overuse Headache Versus Business as Usual

TypeinterventionalSponsorUniversity Hospital, AkershusRan2011 to 2013Enrolled123ConditionsMedication-overuse Headache, Chronic HeadacheArmsBrief intervention, Business as usual, Screening and outcome evaluation only
NCT06032715 narecruitingnot on this mapstarted 2023, after this paper: background citation

Brief Intervention for Reducing Prolonged Use of Sleep Medication Among Elderly

TypeinterventionalSponsorUniversity Hospital, AkershusRan2023 to 2025Enrolled120ConditionsHarmful Use of HypnoticArmsBI (Brief Intervention)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
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  13. Article
  14. Chronic migraine: Genetics or environment?European journal of neurology · 2021
    Article
  15. Epidemiology and management of medication-overuse headache in the general population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Review
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Espen Saxhaug KristoffersenDepartment of General Practice, Institute of Health and Society, University of Oslo, Blindern, PO Box 1130, 0318, Oslo, Norway. e.s.kristoffersen@medisin.uio.no.
Jørund StraandDepartment of General Practice, Institute of Health and Society, University of Oslo, Blindern, PO Box 1130, 0318, Oslo, Norway.
Kjersti Grøtta VetvikHead and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog, Norway.
Jūratė Šaltytė BenthHØKH, Research Centre, Akershus University Hospital, Lørenskog, Norway.
Michael Bjørn RussellHead and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog, Norway.
Christofer LundqvistHØKH, Research Centre, Akershus University Hospital, Lørenskog, Norway.
University of Oslo · NOAkershus University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledMedication-overuse headache (MOH) is a common health problem. Withdrawal of the overused medication is the treatment of choice. We investigated the long-term effectiveness of brief intervention (BI) for MOH patients in primary care. The BI for MOH in primary care study was a blinded, pragmatic, cluster-randomised controlled trial. 25,486 patients (age 18-50) from 50 general practitioners (GPs) were screened for MOH. GPs defined clusters and 23 GPs were randomised to receive BI training and 27 GPs to continue business as usual (BAU). The GPs assessed their MOH patients with the Severity of Dependence Scale, gave individual feedback about the risk of MOH and advice to reduce headache medication. Primary outcomes, assessed 6 months after the intervention, were reduction in headache and medication days/month. 42% were screening responders. 2.4% had self-reported MOH. A random selection of 104 patients with self-reported MOH were invited, 75 were randomised out of which 60 with a physician-defined MOH diagnosis were included. None were lost to follow-up. BI was significantly better than BAU regarding primary outcomes (p < 0.001-0.018). Headache and medication days were reduced by 5.9 (95% CI 1.1-10.8) and 6.2 (1.1-11.3) more days/month in BI than BAU group. Chronic headache resolved in 63 and 11% in the BI and the BAU group (p < 0.001). Headache-related disability was lower among those who detoxified. In conclusion, BI is an effective treatment in primary care with lasting effect 6 months after the intervention for MOH.

trial registrationClinicalTrials.gov identifier: NCT01314768.

Indexed as

AdolescentAdultAged, 80 and overEducation, Medical, ContinuingFemaleFollow-Up StudiesGeneral PractitionersHeadache Disorders, SecondaryHumansMaleMiddle AgedPain ManagementYoung AdultCluster-randomised trialGeneral practiceMedication-overuse headacheMigraineScreening and brief interventionSeverity of dependence scale

Identifiers

PMID26645391
OpenAlexW2193733821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.