ArticleThe Plant cell2015
MicroRNA miR396 Regulates the Switch between Stem Cells and Transit-Amplifying Cells in Arabidopsis Roots.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.
- Interplay among ZF-HD and GRF transcription factors during Arabidopsis leaf development.Plant physiology · 2023Pooled it
- The multifaceted regulatory network of microRNA396: Orchestrating plant plasticity through coordinating development and various stresses.Journal of integrative plant biology · 2026Review
- Rootstock of distant hybrid activates transcription factors of scion cultivar to promote growth and yield in walnut.Plant biotechnology journal · 2025Article
- Application of a GRF-GIF chimera enhances plant regeneration for genome editing in tomato.Plant biotechnology journal · 2025Article
- A microRNA defines root regeneration.Nature plants · 2025Article
- MicroRNA control of stem cell reconstitution and growth in root regeneration.Nature plants · 2025Article
- Identification of the citrus GRF gene family and its expression in fruit peel thickening mediated by gibberellin.BMC plant biology · 2025Article
- An integrated analysis of miRNA and mRNA expressions in soybean response to boron stress.PloS one · 2025Article
- MicroRNA analysis reveals 2 modules that antagonistically regulate xylem tracheary element development in Arabidopsis.The Plant cell · 2024Article
- Depletion of Gibberellin Signaling Up-RegulatesInternational journal of molecular sciences · 2024Article
- ROS, an Important Plant Growth Regulator in Root Growth and Development: Functional Genes and Mechanism.Biology · 2024Review
- Multi-scale mechanisms driving root regeneration: From regeneration competence to tissue repatterning.The Plant journal : for cell and molecular biology · 2024Review
- The Biosynthesis Process of Small RNA and Its Pivotal Roles in Plant Development.International journal of molecular sciences · 2024Review
- Blocking miR396 activity by overexpression MIM396 improved switchgrass tiller number and biomass yield.Biotechnology for biofuels and bioproducts · 2024Article
- Genome-wide molecular evolution analysis of the GRF and GIF gene families in Plantae (Archaeplastida).BMC genomics · 2024Article
- Genome-wide in-silico analysis of ethylene biosynthesis gene family in Musa acuminata L. and their response under nutrient stress.Scientific reports · 2024Article
- Article
- Growth-regulating factor 15-mediated vascular cambium differentiation positively regulates wood formation in hybrid poplar (Frontiers in plant science · 2024Article
- microRNA165 and 166 modulate response of the Arabidopsis root apical meristem to salt stress.Communications biology · 2023Article
- Enhancing alfalfa resistance to Spodoptera herbivory by sequestering microRNA396 expression.Plant cell reports · 2023Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
To ensure an adequate organ mass, the daughters of stem cells progress through a transit-amplifying phase displaying rapid cell division cycles before differentiating. Here, we show that Arabidopsis thaliana microRNA miR396 regulates the transition of root stem cells into transit-amplifying cells by interacting with GROWTH-REGULATING FACTORs (GRFs). The GRFs are expressed in transit-amplifying cells but are excluded from the stem cells through inhibition by miR396. Inactivation of the GRFs increases the meristem size and induces periclinal formative divisions in transit-amplifying cells. The GRFs repress PLETHORA (PLT) genes, regulating their spatial expression gradient. Conversely, PLT activates MIR396 in the stem cells to repress the GRFs. We identified a pathway regulated by GRF transcription factors that represses stem cell-promoting genes in actively proliferating cells, which is essential for the progression of the cell cycle and the orientation of the cell division plane. If unchecked, the expression of the GRFs in the stem cell niche suppresses formative cell divisions and distorts the organization of the quiescent center. We propose that the interactions identified here between miR396 and GRF and PLT transcription factors are necessary to establish the boundary between the stem cell niche and the transit-amplifying region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.