Evidence map›Paper›PMID 26644996›Full record

ArticleNeuroepigenetics2015

Tet1 Oxidase Regulates Neuronal Gene Transcription, Active DNA Hydroxy-methylation, Object Location Memory, and Threat Recognition Memory.

Dinesh Kumar, Milan Aggarwal, Garrett A Kaas, John Lewis, Jing Wang, Daniel L Ross, Chun Zhong, Andrew Kennedy, Hongjun Song, J David Sweatt

Open access · hybridAbstract read
In one paragraph

Article in Neuroepigenetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. DNA Methylation in Long-Term Memory.Physiology (Bethesda, Md.) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Epigenetics of addiction.Neurochemistry international · 2021
    Review
  16. Review
  17. Article
  18. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  19. Epigenetic Mechanisms of Learning and Memory: Implications for Aging.International journal of molecular sciences · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dinesh KumarDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Milan AggarwalDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Garrett A KaasDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
John LewisDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jing WangDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Daniel L RossDepartment of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chun ZhongInstitute for Cell Engineering, Department of Neurology, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Andrew KennedyDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Hongjun SongInstitute for Cell Engineering, Department of Neurology, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
J David SweattDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · USJohns Hopkins University · US

Funding

Biochemical Mechanisms of Neural PlasticityR01MH057014 · NIMH · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 1996 to 2019
$9.3M
DNA Methylation in Memory FormationR01MH091122 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SWEATT, JOHN DAVID · 2011 to 2015
$1.8M
NIMH NIH HHS R01 MH057014NIMH NIH HHS R01 MH091122
6 · The paper itself

Abstract

A dynamic equilibrium between DNA methylation and demethylation of neuronal activity-regulated genes is crucial for memory processes. However, the mechanisms underlying this equilibrium remain elusive. Tet1 oxidase has been shown to play a key role in the active DNA demethylation in the CNS. In this study, we used

Indexed as

active demethylationchromatinCytosine methylationDNAepigeneticfear conditioninggene expressionHDAChomeostatic plasticityhydroxymethylcytosinelearningmemorymetaplasticitymotor learningneuroepigeneticsTETthreat conditioningtranscriptiontranscription factor

Identifiers

PMID26644996
PMCPMC4669576
OpenAlexW2177651097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.