ArticleJournal of advanced research2015
Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties.
Article in Journal of advanced research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 96 citations in OpenAlex.
- Contact-independent antagonistic activity of endophytic Diaporthe biconispora PBS24-3 against Penicillium spp.: dual culture, culture filtrate, metabolomics, and molecular network analysis.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Multiomics reveals postherbivory tea leaves restructure endophytic microbiota to resist disease and boost saccharide metabolism to promote growth.Horticulture research · 2026Article
- Untapped Mycobiota: A Scoping Review of Endophytic Fungi in Medicinal Plants from Malaysia.Journal of fungi (Basel, Switzerland) · 2026Review
- Biochemical characterisation of a new thermotolerant L-asparaginase produced by Cunninghamella echinulata PA3S12MM isolated from the Atlantic Forest.Archives of microbiology · 2026Article
- Article
- Antioxidant properties and L-asparaginase activities of endophytic fungi from Cymbidium orchids.Folia microbiologica · 2024Article
- Cunninghamella echinulata DSM1905 biofilm-based L-asparaginase production in pneumatically-driven bioreactors.PloS one · 2024Article
- Insights into diversity and L-asparaginase activity of fungal endophytes associated with medicinal plant Grewia hirsuta.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Endophytic Fungi as a Promising Source of Anticancer L-Asparaginase: A Review.Current microbiology · 2023Review
- Bacterial-Mediated Tumor Therapy: Old Treatment in a New Context.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Towards further understanding the applications of endophytes: enriched source of bioactive compounds and bio factories for nanoparticles.Frontiers in plant science · 2023Review
- Cacti as low-cost substrates to produce L-asparaginase by endophytic fungi.World journal of microbiology & biotechnology · 2022Article
- Decolourisation of triphenylmethane dyes by biogenically synthesised iron nanoparticles from fungal extract.Mycology · 2022Article
- Fungal Endophytes to Combat Biotic and Abiotic Stresses for Climate-Smart and Sustainable Agriculture.Frontiers in plant science · 2022Review
- Sequencing and characterization of an L-asparaginase gene from a new species of Penicillium section Citrina isolated from Cerrado.Scientific reports · 2021Article
- Microbial L-asparaginase for Application in Acrylamide Mitigation from Food: Current Research Status and Future Perspectives.Microorganisms · 2021Review
- Natural Products from Endophytic Fungi Associated with Rubiaceae Species.Journal of fungi (Basel, Switzerland) · 2020Review
- Endophytic3 Biotech · 2020Review
- Microbes Producing L-Asparaginase free of Glutaminase and Urease isolated from Extreme Locations of Antarctic Soil and Moss.Scientific reports · 2019Article
- Penicillium and Talaromyces endophytes from Tillandsia catimbauensis, a bromeliad endemic in the Brazilian tropical dry forest, and their potential for L-asparaginase production.World journal of microbiology & biotechnology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endophytes are novel sources of natural bioactive compounds. This study seeks endophytes that produce the anticancer enzyme l-asparaginase, to harness their potential for mass production. Four plants with anticancer properties; Cymbopogon citratus, Murraya koenigii, Oldenlandia diffusa and Pereskia bleo, were selected as host plants. l-Asparaginase-producing endophytes were detected by the formation of pink zones on agar, a result of hydrolyzes of asparagine into aspartic acid and ammonia that converts the phenol red dye indicator from yellow (acidic condition) to pink (alkaline condition). The anticancer enzyme asparaginase was further quantified via Nesslerization. Results revealed that a total of 89 morphotypes were isolated; mostly from P. bleo (40), followed by O. diffusa (25), C. citratus (14) and M. koenigii (10). Only 25 of these morphotypes produced l-asparaginase, mostly from P. bleo and their asparaginase activities were between 0.0069 and 0.025 μM mL(-1) min(-1). l-Asparaginase producing isolates were identified as probable species of the genus Colletotrichum, Fusarium, Phoma and Penicillium. Studies here revealed that endophytes are good alternative sources for l-asparaginase production and they can be sourced from anticancer plants, particularly P. bleo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.