ReviewBoneKEy reports2015
Treatment of bone marrow lesions (bone marrow edema).
Review in BoneKEy reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The relationship between MRI-detected hip abnormalities and hip pain in hip osteoarthritis: a systematic review.Rheumatology international · 2024Pooled it
- Effect of Recombinant Human Parathyroid Hormone (1-84) on Resolution of Active Charcot Neuro-osteoarthropathy in Diabetes: A Randomized, Double-Blind, Placebo-Controlled Study.Diabetes care · 2021Trial
- Validation of a new topographic classification of bone marrow lesions in the knee: the six-letter system.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Trial
- Bone marrow lesions in osteoarthritis: biomarker or treatment target? A narrative review.Skeletal radiology · 2025Review
- No Significant Differences between Bisphosphonates and Placebo for the Treatment of Bone Marrow Lesions of the Knee: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- Preoperative patellar bone marrow lesions with full thickness cartilage defects correlate with residual anterior knee pain in total knee arthroplasty without patellar resurfacing.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Bone marrow lesions: plugging the holes in our knowledge using animal models.Nature reviews. Rheumatology · 2023Review
- Calcium Phosphate Cements Combined with Blood as a Promising Tool for the Treatment of Bone Marrow Lesions.Journal of functional biomaterials · 2023Article
- Spontaneous Bone Marrow Edema: Perfusion Abnormalities and Treatment with Surgical Decompression.International journal of molecular sciences · 2023Article
- Experimental models of bone marrow lesions in ovine femoral condyles.Veterinary surgery : VS · 2023Article
- Bone marrow lesions of the femoral head: can radiomics distinguish whether it is reversible?Polish journal of radiology · 2023Article
- How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Transient Hip Osteoporosis: Etiopathogenetic, Clinical, and Imaging Approach.Mediterranean journal of rheumatology · 2022Review
- Cross-Sectional Imaging Useful in Melorheostosis.JBMR plus · 2021Article
- Influence of the Mechanical Environment on the Regeneration of Osteochondral Defects.Frontiers in bioengineering and biotechnology · 2021Review
- Percutaneous Skeletal Fixation of Painful Subchondral Bone Marrow Edema Utilizing an Injectable, Synthetic, Biocompatible Hyaluronic Acid-Based Bone Graft Substitute.Arthroscopy techniques · 2020Article
- Percutaneous Skeletal Fixation of Painful Subchondral Bone Marrow Edema of the Knee.Arthroscopy, sports medicine, and rehabilitation · 2020Article
- Complex regional pain syndrome and bone marrow oedema syndrome: family ties potentially closer than expected.BMJ case reports · 2020Article
- Relationship between radiological severity and physical and mental health in elderly individuals with knee osteoarthritis.Arthritis research & therapy · 2020Article
- Management of Bone Marrow Lesions of the Hip With Subchondral Calcium Phosphate Injection: Surgical Technique and Tips.Arthroscopy techniques · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow lesions (BMLs) or using older terminology 'Bone marrow edema' is characterised by excessive water signals in the marrow space on magnetic resonance imaging or ultrasound; BMLs constitute a central component of a wide variety of inflammatory and non-inflammatory rheumatologic conditions affecting the musculoskeletal system: BMLs are not only considered significant sources of pain but also linked to increased disease activity in many musculoskeletal conditions (for example, osteoarthritis, rheumatoid arthritis). The purpose of this review is to summarise current knowledge about the treatment of BMLs, with an emphasis on the clinical and histological features of this entity in inflammatory and non-inflammatory disease. We also try to pair this hypothesis with the apparent beneficial effects of various treatment regimens, mainly within the group of bone antiresorptive drugs (calcitonin, bisphosphonates) on symptoms associated with BMLs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.